Results of the ALLHAT Trial: is the Debate About Initial Antihypertensive Drug Therapy Over?

Overview

Journal J Clin Hypertens (Greenwich)

Specialty Cardiology & Vascular Diseases

Date 2003 Jan 31

PMID 12556646

Citations 2

Authors

Marvin Moser

Affiliations

Soon will be listed here.

Citing Articles

Managing high-risk patients with hypertension: focus on the renin-angiotensin system.

Gradman A J Clin Hypertens (Greenwich). 2004; 6(9):501-8.

PMID: 15365277 PMC: 8109372. DOI: 10.1111/j.1524-6175.2004.03524.x.

Here we go again.

Moser M J Clin Hypertens (Greenwich). 2003; 5(2):103-4.

PMID: 12671321 PMC: 8099252. DOI: 10.1111/j.1524-6175.2003.02444.x.

References

McInnes G, Yeo W, Ramsay L, Moser M . Cardiotoxicity and diuretics: much speculation--little substance. J Hypertens. 1992; 10(4):317-35. DOI: 10.1097/00004872-199204000-00002. View

Moser M . Diuretics revisited--again. J Clin Hypertens (Greenwich). 2001; 3(3):136-38. PMC: 8099320. DOI: 10.1111/j.1524-6175.2001.00468.x. View

Moser M . Suppositions and speculations--their possible effects on treatment decisions in the management of hypertension. Am Heart J. 1989; 118(6):1362-9. DOI: 10.1016/0002-8703(89)90059-8. View

Brenner B, Cooper M, de Zeeuw D, Keane W, Mitch W, Parving H . Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med. 2001; 345(12):861-9. DOI: 10.1056/NEJMoa011161. View

Hebert P, Moser M, Mayer J, Glynn R, Hennekens C . Recent evidence on drug therapy of mild to moderate hypertension and decreased risk of coronary heart disease. Arch Intern Med. 1993; 153(5):578-81. View

Moser M, Ross H . The treatment of hypertension in diabetic patients. Diabetes Care. 1993; 16(2):542-7. DOI: 10.2337/diacare.16.2.542. View

. The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Arch Intern Med. 1997; 157(21):2413-46. DOI: 10.1001/archinte.157.21.2413. View

. Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA. 2000; 283(15):1967-75. View

Moser M, Hebert P . Prevention of disease progression, left ventricular hypertrophy and congestive heart failure in hypertension treatment trials. J Am Coll Cardiol. 1996; 27(5):1214-8. DOI: 10.1016/0735-1097(95)00606-0. View

10.

Cushman W, Ford C, Cutler J, Margolis K, Davis B, Grimm R . Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich). 2002; 4(6):393-404. DOI: 10.1111/j.1524-6175.2002.02045.x. View

11.

Hollifield J . Potassium and magnesium abnormalities: diuretics and arrhythmias in hypertension. Am J Med. 1984; 77(5A):28-32. DOI: 10.1016/s0002-9343(84)80005-4. View

12.

Neaton J, Grimm Jr R, Prineas R, Stamler J, Grandits G, Elmer P . Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group. JAMA. 1993; 270(6):713-24. View

13.

Agodoa L, Appel L, Bakris G, Beck G, BOURGOIGNIE J, Briggs J . Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA. 2001; 285(21):2719-28. DOI: 10.1001/jama.285.21.2719. View

14.

Houston M . New insights and new approaches for the treatment of essential hypertension: selection of therapy based on coronary heart disease risk factor analysis, hemodynamic profiles, quality of life, and subsets of hypertension. Am Heart J. 1989; 117(4):911-51. DOI: 10.1016/0002-8703(89)90631-5. View

15.

Lewis E, Hunsicker L, Clarke W, Berl T, Pohl M, Lewis J . Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001; 345(12):851-60. DOI: 10.1056/NEJMoa011303. View

16.

Moser M . Can the cost of care be contained and quality of care maintained in the management of hypertension?. Arch Intern Med. 1994; 154(15):1665-72. DOI: 10.1001/archinte.154.15.1665. View

17.

Holland O, Nixon J, Kuhnert L . Diuretic-induced ventricular ectopic activity. Am J Med. 1981; 70(4):762-8. DOI: 10.1016/0002-9343(81)90530-1. View

18.

Dahlof B, Devereux R, Kjeldsen S, Julius S, Beevers G, de Faire U . Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 2002; 359(9311):995-1003. DOI: 10.1016/S0140-6736(02)08089-3. View

19.

Papademetriou V, Burris J, Notargiacomo A, FLETCHER R, FREIS E . Thiazide therapy is not a cause of arrhythmia in patients with systemic hypertension. Arch Intern Med. 1988; 148(6):1272-6. View

20.

. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group. JAMA. 1991; 265(24):3255-64. View