Arabidopsis Mutants Sensitive to Gamma Radiation Include the Homologue of the Human Repair Gene ERCC1

Overview

Journal J Exp Bot

Publisher Oxford University Press

Specialty Biology

Date 2003 Jan 30

PMID 12554710

Citations 36

Authors

E Hefner

S B Preuss

A B Britt

Affiliations

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Abstract

Mutants sensitive to ionizing radiation in yeast and mammals include an assortment of DNA repair genes. The majority of these DNA repair genes are involved in the repair of DNA double-strand breaks. In this study a forward genetic screen is used to identify gamma-sensitive mutants of Arabidopsis thaliana. The gamma-plantlet screen used here also reveals two general mutant classes based on size of cotyledons and hypocotyls. One of the mutants discovered is a homologue of the mammalian nucleotide excision repair gene ERCC1.

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