GABA(A) Receptor Function and Pharmacology in Epilepsy and Status Epilepticus

Overview

Journal Curr Opin Pharmacol

Specialty Pharmacology

Date 2003 Jan 29

PMID 12550736

Citations 30

Authors

Dorothy M Jones-Davis

Robert L Macdonald

Affiliations

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Abstract

GABA(A) (gamma-n-aminobutyric acid) receptor dysfunction has long been implicated in the development of epilepsy and status epilepticus. Recent advances have been made in understanding the cellular, pharmacological and genetic involvement of GABA(A) receptors in seizure disorders. In particular, genetic mutations found in GABA(A) receptor subunits strongly implicate the GABA(A) receptor in idiopathic generalised epilepsies.

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