Phenytoin Decreases the Blood Concentrations of Sirolimus in a Liver Transplant Recipient: a Case Report

Overview

Journal Ther Drug Monit

Specialty Pharmacology

Date 2003 Jan 28

PMID 12548156

Citations 7

Authors

Jonathan A Fridell

Ashok Kumar B Jain

Kusum Patel

Mohamed Virji

K N Rao

John J Fung

Raman Venkataramanan

Affiliations

Soon will be listed here.

Abstract

This report documents that coadministration of phenytoin leads to decreased blood concentrations and area under the blood concentration-time curve of sirolimus in a liver transplant patient. It is essential to monitor the blood concentrations of sirolimus and adjust the sirolimus dosage when phenytoin administration begins or ends.

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