Structure and Mechanism of the Oestrogen Receptor

Overview

Journal Biochem Soc Trans

Specialty Biochemistry

Date 2003 Jan 28

PMID 12546653

Citations 22

Authors

E H Kong

A C W Pike

R E Hubbard

Affiliations

Soon will be listed here.

Abstract

We have determined the structures of the oestrogen receptor ligand-binding domain in complex with a range of ligands and with fragments of co-regulator proteins. These structures provide insights into the structural mechanisms underlying the receptor's complex pharmacological properties and how the conformation of the receptor modulates its ability to recruit co-regulators that are necessary for transcriptional activation.

Citing Articles

Associations of urinary phytoestrogens with all-cause and cardiovascular mortality in adults: a population-based cohort study.

Xuan C, Zhao C, Zhou T, Guo J, Pan D, Wang Z Front Endocrinol (Lausanne). 2024; 15:1400182.

PMID: 39319255 PMC: 11419972. DOI: 10.3389/fendo.2024.1400182.

Estrogen receptors alpha and beta expression in different canine cancer types with an emphasis on hematopoietic malignancies.

Bugiel-Stabla K, Agnoli C, Pawlak A Vet Res Commun. 2024; 48(4):1977-1990.

PMID: 38594602 DOI: 10.1007/s11259-024-10368-2.

estrogen receptor alpha antagonist studies and toxicity prediction of leaves bioactive ethyl acetate fraction.

Ervina M, Pratama M, Poerwono H, Ekowati J, Widyowati R, Matsunami K J Adv Pharm Technol Res. 2021; 12(3):236-241.

PMID: 34345601 PMC: 8300330. DOI: 10.4103/japtr.JAPTR_198_21.

Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases.

Bozovic A, Mandusic V, Todorovic L, Krajnovic M Int J Mol Sci. 2021; 22(4).

PMID: 33562134 PMC: 7914503. DOI: 10.3390/ijms22041656.

ER-α36 mediates gastric cancer cell invasion.

Wang X, Yuan C, Jin Y, Huang H, Sheng X, Wei W Int J Clin Exp Pathol. 2020; 13(7):1550-1559.

PMID: 32782673 PMC: 7414493.