Evidence for the Secretory Transport Mechanism of Intestinal Immunoglobulin. The Ultrastructural Distribution of IgM

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1976 Mar 1

PMID 1254322

Citations 2

Authors

W D Allen

C G Smith

P Porter

Affiliations

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Abstract

The intracellular localization of IgM in porcine intestinal tissue has been studied by immunoelectron microscopy and immunofluorescence. IgM was demonstrated in vesicles in the cytoplasm of crypt epithelial cells particularly in the supranuclear region. It was also shown in the ergastoplasmic cisternae of plasma cells in the intercryptal lamina propria. The findings are compared with those of a previous similar study on secretory IgA and their implications for possible mechanisms of selective transport are discussed.

Citing Articles

Serum protein content of rat small-intestinal mucus.

Lukie B Dig Dis Sci. 1986; 31(1):73-8.

PMID: 3079696 DOI: 10.1007/BF01347912.

The relative frequencies and distribution of immunoglobulin-bearing cells in the intestinal mucosa of neonatal and weaned pigs and their significance in the development of secretory immunity.

Allen W, Porter P Immunology. 1977; 32(5):819-24.

PMID: 863476 PMC: 1445329.

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