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Sequence of Centromere Separation of Mitotic Chromosomes in Chinese Hamster

Overview
Journal Chromosoma
Specialty Molecular Biology
Date 1976 Mar 31
PMID 1253649
Citations 7
Authors
B K Vig
H G Miltenburger
Affiliations
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Abstract

Chromosome preparation in late metaphase cells from bone marrow of colcemid treated male Chinese hamsters were used to analyse the sequence of separation of sister centromeres. Chromatids of chromosomes 2 and 1 are the first ones to separate at centromeres, followed by members of group B, D and C. Some acrocentric chromosome is always the last one to separate at the centromere. The data point to a possible correlation between the position of a centromere in the separation sequence in the genome and the amount of centromeric heterochromatin as well as relation to the phenomenon of non-disjunction.

Citing Articles

The effect of cyclophosphamide and isoniazid (INH) alone and in combination on the centromere separation sequence in Chinese hamster bone marrow cells.

Miltenburger H, Singh J, Barth B Hum Genet. 1980; 54(1):93-6.

PMID: 7390486 DOI: 10.1007/BF00279055.

Centromere separation: existence of sequences.

Vig B Experientia. 1981; 37(6):566-7.

PMID: 7262276 DOI: 10.1007/BF01990051.

Sequence of centromere separation: analysis of mitotic chromosomes in man.

Vig B Hum Genet. 1981; 57(3):247-52.

PMID: 7250964 DOI: 10.1007/BF00278937.

Premature centromere splitting in a presumptive mild form of Roberts syndrome.

Petrinelli P, Antonelli A, Marcucci L, Dallapiccola B Hum Genet. 1984; 66(1):96-9.

PMID: 6698562 DOI: 10.1007/BF00275195.

Sequence of centromere separation another mechanism for the origin of nondisjunction.

Vig B Hum Genet. 1984; 66(2-3):239-43.

PMID: 6232200 DOI: 10.1007/BF00286609.

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