Do Cognitive Patterns of Brain Magnetic Activity Correlate with Hippocampal Atrophy in Alzheimer's Disease?

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 2003 Jan 18

PMID 12531952

Citations 10

Authors

F Maestu

J Arrazola

A Fernandez

P G Simos

C Amo

P Gil-Gregorio

S Fernandez

A Papanicolaou

T Ortiz

Affiliations

Soon will be listed here.

Abstract

Background: Many reports support the clinical validity of volumetric MRI measurements in Alzheimer's disease.

Objective: To integrate functional brain imaging data derived from magnetoencephalography (MEG) and volumetric data in patients with Alzheimer's disease and in age matched controls.

Methods: MEG data were obtained in the context of a probe-letter memory task. Volumetric measurements were obtained for lateral and mesial temporal lobe regions.

Results: As expected, Alzheimer's disease patients showed greater hippocampal atrophy than controls bilaterally. MEG derived indices of the degree of activation in left parietal and temporal lobe areas, occurring after 400 ms from stimulus onset, correlated significantly with the relative volume of lateral and mesial temporal regions. In addition, the size of the right hippocampus accounted for a significant portion of the variance in cognitive scores independently of brain activity measures.

Conclusions: These data support the view that there is a relation between hippocampal atrophy and the degree of neurophysiological activity in the left temporal lobe.

Citing Articles

An Overview of ICA/BSS-Based Application to Alzheimer's Brain Signal Processing.

Yang W, Pilozzi A, Huang X Biomedicines. 2021; 9(4).

PMID: 33917280 PMC: 8067382. DOI: 10.3390/biomedicines9040386.

A Comprehensive Review of Magnetoencephalography (MEG) Studies for Brain Functionality in Healthy Aging and Alzheimer's Disease (AD).

Mandal P, Banerjee A, Tripathi M, Sharma A Front Comput Neurosci. 2018; 12:60.

PMID: 30190674 PMC: 6115612. DOI: 10.3389/fncom.2018.00060.

Magnetoencephalography.

Proudfoot M, Woolrich M, Nobre A, Turner M Pract Neurol. 2014; 14(5):336-43.

PMID: 24647614 PMC: 4174130. DOI: 10.1136/practneurol-2013-000768.

Neurotoxic saboteurs: straws that break the hippo's (hippocampus) back drive cognitive impairment and Alzheimer's Disease.

Daulatzai M Neurotox Res. 2013; 24(3):407-59.

PMID: 23820984 DOI: 10.1007/s12640-013-9407-2.

Magnetoencephalography as a putative biomarker for Alzheimer's disease.

Zamrini E, Maestu F, Pekkonen E, Funke M, Makela J, Riley M Int J Alzheimers Dis. 2011; 2011:280289.

PMID: 21547221 PMC: 3087473. DOI: 10.4061/2011/280289.

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