ROMP-generated Oligomeric Sulfonyl Chlorides As Versatile Soluble Scavenging Agents

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2003 Jan 17

PMID 12529116

Citations 7

Authors

Joel D Moore

Russell H Herpel

Joy R Lichtsinn

Daniel L Flynn

Paul R Hanson

Affiliations

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Abstract

[reaction: see text] A new method for homogeneous nucleophilic scavenging employing oligomeric sulfonyl chloride (OSC) reagents is described. The method utilizes OSC to rapidly scavenge a variety of amines that are present in excess. The OSC reagents are generated from ROM polymerization of 2-chlorosulfonyl-5-norbornene utilizing the second generation Grubbs catalyst to produce oligomers of varying size as stable, free-flowing powders. Following the scavenging event, these oligomers are precipitated with ethyl acetate leaving products in excellent yield and purity.

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