[Preliminary Investigation of the Relationship Between Liver Lesion and Relevant Factors in Young Children with Rotavirus Diarrhea]

Objective: To investigate the possibility of liver lesion and its relationship with the relative factors in young children with rotavirus(RV) diarrhea.

Methods: The values of ALT and AST in sera of young children with RV diarrhea were measured to be compared with those of common diarrhea and were analyzed with the multifactors about diarrhea. The genomes of RV from blood serum were tested with reverse-nest polymerase chain reaction.

Results: Of the 41 young children with RV diarrhea, 15(36.6%) and 32 cases (75.6%) were abnormally higher in the level of ALT and AST respectively and both the ratio and degree of increase were significant in comparison with that in control group. There was no significant relation between the changes of the values of ALT and AST and the clinical manifestation of diarrhea. 4 out of 41 cases were found to be positive of viremia.

Conclusion: RV infection might spread from intestine to blood and to other organs resulting in viremia, and the liver may be one of the organs involved.