Experimental Mucosal Infection with Molecularly Cloned Feline Immunodeficiency Viruses

Overview

Journal Clin Diagn Lab Immunol

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2003 Jan 11

PMID 12522061

Citations 1

Authors

Mariko Kohmoto

Yasuhiro Ikeda

Eiji Sato

Yorihiro Nishimura

Yasuo Inoshima

Masayuki Shimojima

Yukinobu Tohya

Takeshi Mikami

Takayuki Miyazawa

Affiliations

Soon will be listed here.

Abstract

Four of six specific pathogen-free cats were infected after intravaginal exposure to molecularly cloned lymphotropic but non-Crandell feline kidney (CRFK)-tropic feline immunodeficiency virus strain TM2 and its AP-1 deletion mutant. The sequences of the env V3-to-V5 region which defines the CRFK tropism were unchanged in the infected cats through the infection. These data suggest that the strain was transmitted across the mucosal epithelium without a broadening of cell tropism.

Citing Articles

Antiretroviral spermicide WHI-07 prevents vaginal and rectal transmission of feline immunodeficiency virus in domestic cats.

DCruz O, Waurzyniak B, Uckun F Antimicrob Agents Chemother. 2004; 48(4):1082-8.

PMID: 15047505 PMC: 375320. DOI: 10.1128/AAC.48.4.1082-1088.2004.

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