Angiogenesis in Pterygium: Morphometric and Immunohistochemical Study

Overview

Journal Curr Eye Res

Publisher Informa Healthcare

Specialty Ophthalmology

Date 2003 Jan 9

PMID 12518239

Citations 35

Authors

Arie L Marcovich

Yair Morad

Judith Sandbank

Monica Huszar

Mordechai Rosner

Ayala Pollack

Mehrdad Herbert

Yaron Bar-Dayan

Affiliations

Soon will be listed here.

Abstract

Objective: To evaluate the role of angiogenesis in the pathogenesis of pterygium by comparing the expression of von-Willebrand factor (vWF) and vascular endothelial growth factor (VEGF) in pterygium, and in normal superior bulbar conjunctiva.

Methods: 23 human samples from pterygium and the superior bulbar conjunctiva were stained using rabbit anti-vWF and anti-VEGF antibodies. The density of vWF and VEGF positive vessels, VEGF staining intensity and the number of VEGF positive stromal, epithelial and vascular endothelial cells were evaluated.

Results: Pterygium specimens had higher average vWF and VEGF positive microvascular counts per high power field (P = 0.0012), higher average VEGF staining intensity scores in epithelial, stromal and endothelial cells (p < 0.0001) and higher VEGF positive cell counts (P < 0.0001) than normal conjuctiva.

Conclusions: Over-expression of VEGF in pterygium tissue, together with the abundance of vWF-stained new vessels, may support previous suggestions that angiogenesis may play a role in the formation of pterygium.

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Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.

Liu X, Zhang J, Nie D, Zeng K, Hu H, Tie J Front Genet. 2021; 12:646550.

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Role of oxidative stress and vascular endothelial growth factor expression in pterygium pathogenesis and prevention of pterygium recurrence after surgical excision.

Elgouhary S, Elmazar H, Naguib M, Bayomy N Int Ophthalmol. 2020; 40(10):2593-2606.

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