Metabolic Impact of Body Fat Distribution

Overview

Journal J Endocrinol Invest

Publisher Springer

Specialty Endocrinology

Date 2003 Jan 2

PMID 12508950

Citations 23

Authors

C Gasteyger

A Tremblay

Affiliations

Soon will be listed here.

Abstract

Many studies have shown that fat distribution influences metabolism independently of the effects of total body fat stores. The accumulation of fat in the abdominal area, particularly in the visceral fat compartment, seems to be associated with an increased risk to display complications such as insulin resistance, diabetes, dyslipidemias and atherosclerosis. As reviewed in this paper, the mechanisms explaining this impact of fat distribution is not clearly established, although evidence suggests that free-fatty acids, leptin, TNF-alpha, PPAR-gamma, and F are directly or indirectly involved in this process. Despite a lot of research has yet to be performed to mechanistically characterize the impact of visceral fat on the metabolic profile, there is enough consensus in the literature about its effect to justify its consideration in a clinical setting. In this regard, the use of waist circumference as a clinical marker of variations in visceral fat is highly relevant and should be encouraged. This review also presents an evolutionary perspective according to which body fat gain would have been and may still remain an adaptation that helps to deal with stress and inflammation.

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References

Hotamisligil G . The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med. 1999; 245(6):621-5. DOI: 10.1046/j.1365-2796.1999.00490.x. View

Rieusset J, Andreelli F, Auboeuf D, Roques M, Vallier P, Riou J . Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes. Diabetes. 1999; 48(4):699-705. DOI: 10.2337/diabetes.48.4.699. View

VAGUE J . Sexual differentiation; Factor determining forms of obesity. Presse Med (1893). 1947; 55(30):339. View

Cnop M, Landchild M, Vidal J, Havel P, Knowles N, Carr D . The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes. 2002; 51(4):1005-15. DOI: 10.2337/diabetes.51.4.1005. View

Hotamisligil G, Shargill N, Spiegelman B . Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993; 259(5091):87-91. DOI: 10.1126/science.7678183. View

Holub M, Zwiauer K, Winkler C, Dillinger-Paller B, Schuller E, Schober E . Relation of plasma leptin to lipoproteins in overweight children undergoing weight reduction. Int J Obes Relat Metab Disord. 1999; 23(1):60-6. DOI: 10.1038/sj.ijo.0800759. View

Arner P . Not all fat is alike. Lancet. 1998; 351(9112):1301-2. DOI: 10.1016/S0140-6736(05)79052-8. View

Mauriege P, Galitzky J, Berlan M, Lafontan M . Heterogeneous distribution of beta and alpha-2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. Eur J Clin Invest. 1987; 17(2):156-65. DOI: 10.1111/j.1365-2362.1987.tb02395.x. View

Bjorntorp P . "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis. 1990; 10(4):493-6. View

10.

Saghizadeh M, Ong J, Garvey W, Henry R, Kern P . The expression of TNF alpha by human muscle. Relationship to insulin resistance. J Clin Invest. 1996; 97(4):1111-6. PMC: 507159. DOI: 10.1172/JCI118504. View

11.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman J . Positional cloning of the mouse obese gene and its human homologue. Nature. 1994; 372(6505):425-32. DOI: 10.1038/372425a0. View

12.

Cseh K, Winkler G, Melczer Z, Baranyi E . The role of tumour necrosis factor (TNF)-alpha resistance in obesity and insulin resistance. Diabetologia. 2000; 43(4):525. DOI: 10.1007/s001250051339. View

13.

Cigolini M, Smith U . Human adipose tissue in culture. VIII. Studies on the insulin-antagonistic effect of glucocorticoids. Metabolism. 1979; 28(5):502-10. DOI: 10.1016/0026-0495(79)90189-6. View

14.

Unger R, Orci L . Lipotoxic diseases of nonadipose tissues in obesity. Int J Obes Relat Metab Disord. 2000; 24 Suppl 4:S28-32. DOI: 10.1038/sj.ijo.0801498. View

15.

Lottenberg S, Giannella-Neto D, Derendorf H, Rocha M, Bosco A, Carvalho S . Effect of fat distribution on the pharmacokinetics of cortisol in obesity. Int J Clin Pharmacol Ther. 1998; 36(9):501-5. View

16.

Liuzzi A, Savia G, Tagliaferri M, Lucantoni R, Berselli M, Petroni M . Serum leptin concentration in moderate and severe obesity: relationship with clinical, anthropometric and metabolic factors. Int J Obes Relat Metab Disord. 1999; 23(10):1066-73. DOI: 10.1038/sj.ijo.0801036. View

17.

Shor-Posner G, Campa A, Zhang G, Persaud N, Miguez-Burbano M, Quesada J . When obesity is desirable: a longitudinal study of the Miami HIV-1-infected drug abusers (MIDAS) cohort. J Acquir Immune Defic Syndr. 2000; 23(1):81-8. DOI: 10.1097/00126334-200001010-00011. View

18.

Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjostrom L . Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J (Clin Res Ed). 1984; 289(6454):1257-61. PMC: 1443498. DOI: 10.1136/bmj.289.6454.1257. View

19.

Marin P, Darin N, Amemiya T, Andersson B, Jern S, Bjorntorp P . Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism. 1992; 41(8):882-6. DOI: 10.1016/0026-0495(92)90171-6. View

20.

Fernandez-Real J, Ricart W . Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness. Diabetologia. 1999; 42(11):1367-74. DOI: 10.1007/s001250051451. View