The Anti-inflammatory Actions of Tilorone Hydrochloride

Overview

Journal Proc Soc Exp Biol Med

Specialties Biology
General Medicine
Physiology

Date 1975 May 1

PMID 124872

Citations 8

Authors

H MEGEL

A Raychaudhuri

I SHEMANO

T H BEAVER

L L Thomas

Affiliations

Soon will be listed here.

Abstract

Tilorone suppressed inflammation induced by immune (direct passive Arthus reaction) as well as by non-immune agents (carrageenam-induced paw edema and abscess formation), if the compound is given 24 hr prior to the proinflammatory agonists. The non-immune anti-inflammatory effect is independent of the adrenals. A surprising findings was that total serum hemolytic complement is markedly elevated 24 hr after a single dose of tilorone.

Citing Articles

An Effective Synthesis Method for Tilorone Dihydrochloride with Obvious IFN-α Inducing Activity.

Zhang J, Yao Q, Liu Z Molecules. 2015; 20(12):21458-63.

PMID: 26633340 PMC: 6332401. DOI: 10.3390/molecules201219781.

2,6-Di-tert-butyl-4-(2'-thenoyl)phenol(R-830): a novel nonsteroidal anti-inflammatory agent with antioxidant properties.

Moore G, SWINGLE K Agents Actions. 1982; 12(5-6):674-83.

PMID: 6819772 DOI: 10.1007/BF01965078.

Dissociation between antiinflammatory action of tilorone and its interferon inducing activity.

Hiyama Y, Kuriyama K Agents Actions. 1991; 33(3-4):229-32.

PMID: 1719782 DOI: 10.1007/BF01986567.

[The regulation of acute inflammatory processes by systemic changes of plasma protein profiles].

Scherer R, Ruhenstroth-Bauer G Naturwissenschaften. 1977; 64(9):471-8.

PMID: 917121 DOI: 10.1007/BF00446258.

Renal lesions induced induced by tilorone and an analog. Ultrastructure and acid phosphatase study.

Thelmo W, Levine S Am J Pathol. 1978; 91(2):355-60.

PMID: 645830 PMC: 2018211.