Anterior-posterior Polarity in C. Elegans and Drosophila--PARallels and Differences

Overview

Journal Science

Specialty Science

Date 2002 Dec 10

PMID 12471246

Citations 36

Authors

Jason Pellettieri

Geraldine Seydoux

Affiliations

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Abstract

The eggs of Caenorhabditis elegans and Drosophila bear little similarity to each other, yet both depend on the par genes for control of anterior-posterior polarity. Here we explore possible common roles for the par genes (pars) in converting transient asymmetries into stably polarized axes. Although clear mechanistic parallels remain to be established, par-dependent regulation of microtubule dynamics and protein stability emerge as common themes.

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