Mimicry of Bioactive Peptides Via Non-natural, Sequence-specific Peptidomimetic Oligomers

Overview

Journal Curr Opin Chem Biol

Publisher Elsevier

Specialty Biochemistry

Date 2002 Dec 10

PMID 12470744

Citations 42

Authors

James A Patch

Annelise E Barron

Affiliations

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Abstract

Non-natural, sequence-specific peptidomimetic oligomers are being designed to mimic bioactive peptides, with potential therapeutic application. Cationic, facially amphipathic helical beta-peptide oligomers have been developed as magainin mimetics. Non-natural mimics of HIV-Tat protein, lung surfactant proteins, collagen, and somatostatin are also being developed. Pseudo-tertiary structure in beta-peptides and peptoids may herald the creation of entirely artificial proteins.

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