Molecular Signaling in Death Receptor and Mitochondrial Pathways of Apoptosis (Review)

Overview

Journal Int J Oncol

Specialty Oncology

Date 2002 Dec 7

PMID 12469180

Citations 73

Authors

Sudhir Gupta

Affiliations

Soon will be listed here.

Abstract

In recent years major progress has been made in understanding the molecular steps of death receptor and mitochondrial pathway of apoptosis. Mechanisms of NF-kappaB-mediated survival (anti-apoptotic) signal have been delineated. A novel anti-apoptotic mechanism of FLIP in the recruitment of RIP and TRAF-1 and TRAF-2 to activate ERK and NF-kappaB has been defined. These are some of the recent discoveries in death receptor and mitochondrial pathways of apoptosis that have been reviewed in this article.

Citing Articles

Independent organelle and organelle-organelle interactions: essential mechanisms for malignant gynecological cancer cell survival.

Shen Y, Chen Q, Li C, Han F Front Immunol. 2024; 15:1393852.

PMID: 38711526 PMC: 11070488. DOI: 10.3389/fimmu.2024.1393852.

Akkermania muciniphila: a rising star in tumor immunology.

Wang L, Tang D Clin Transl Oncol. 2024; 26(10):2418-2430.

PMID: 38653927 DOI: 10.1007/s12094-024-03493-6.

Emerging role of vitamin D in alleviating intestinal structure injury caused by in grass carp ().

Zhang Y, Zhou X, Jiang W, Wu P, Liu Y, Ren H Anim Nutr. 2024; 16:202-217.

PMID: 38362511 PMC: 10867611. DOI: 10.1016/j.aninu.2023.07.010.

Vitamin D Promotes Mucosal Barrier System of Fish Skin Infected with through Multiple Modulation of Physical and Immune Protective Capacity.

Zhang Y, Zhou X, Jiang W, Wu P, Liu Y, Ren H Int J Mol Sci. 2023; 24(14).

PMID: 37511003 PMC: 10379486. DOI: 10.3390/ijms241411243.

Hot Water Extract of (Hack.) Makino & Shibata Abate Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis in Kidney Epithelial Cells.

Fernando I, Kirindage K, Jayasinghe A, Han E, Dias M, Kang K Antioxidants (Basel). 2022; 11(5).

PMID: 35624876 PMC: 9137972. DOI: 10.3390/antiox11051013.