Adenosine: a Neuron-glial Transmitter Promoting Myelination in the CNS in Response to Action Potentials

Overview

Journal Neuron

Publisher Cell Press

Specialty Neurology

Date 2002 Dec 7

PMID 12467589

Citations 235

Authors

Beth Stevens

Stefania Porta

Laurel L Haak

Vittorio Gallo

R Douglas Fields

Affiliations

Soon will be listed here.

Abstract

Neuronal activity influences myelination of the brain, but the molecular mechanisms involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) express functional adenosine receptors, which are activated in response to action potential firing. Adenosine acts as a potent neuron-glial transmitter to inhibit OPC proliferation, stimulate differentiation, and promote the formation of myelin. This neuron-glial signal provides a molecular mechanism for promoting oligodendrocyte development and myelination in response to impulse activity and may help resolve controversy on the opposite effects of impulse activity on myelination in the central and peripheral nervous systems.

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