Analysis of Gene Polymorphisms in the Regulatory Region of MCP-1, RANTES, and CCR5 in Liver Transplant Recipients

Overview

Journal J Clin Immunol

Publisher Springer

Specialty Allergy & Immunology

Date 2002 Dec 5

PMID 12462338

Citations 1

Authors

Bernd Schroppel

Michael Fischereder

Marvin Lin

Brad Marder

Tom Schiano

Bernhard K Kramer

Barbara Murphy

Affiliations

Soon will be listed here.

Abstract

Chemokines and their receptors play a major role in the inflammatory and immune responses that mediate allograft outcome. The production of some chemokines varies among individuals and these variations may be determined by genetic polymorphisms, most commonly within the regulatory region of the gene. We investigated whether the functional polymorphisms of the chemokines RANTES, MCP-1 and chemokine receptor CCR5 are associated with the incidence of acute rejection and long-term liver graft survival. Two hundred nine liver transplant recipients were genotyped using polymerase chain reaction sequence-specific primers for the following polymorphisms: RANTES-28, MCP-1 -2518, and CCR5-59029. There was no association with any of the three genotypes and the incidence of acute rejection episodes. In addition, no association of RANTES-28, MCP-1 -2518, or CCR5 -59029 variants with long-term liver graft survival was found. In conclusion, variants of RANTES-28, MCP-1 -2518, and CCR5-59029 neither influenced the incidence of acute rejection nor affected long-term allograft survival upon liver transplantation in the context of this analysis.

Citing Articles

Chemokine (CCR) and fractalkine (CX3CR) receptors and end stage renal disease.

Borkar M, Tripathi G, Sharma R, Sankhwar S, Agrawal S Inflamm Res. 2010; 60(4):399-407.

PMID: 21132346 DOI: 10.1007/s00011-010-0284-3.

References

Moore S . Is HLA matching beneficial in liver transplantation?. Liver Transpl. 2001; 7(9):774-6. DOI: 10.1053/jlts.2001.26924. View

Song E, Zou H, Yao Y, Proudfoot A, Antus B, Liu S . Early application of Met-RANTES ameliorates chronic allograft nephropathy. Kidney Int. 2002; 61(2):676-85. DOI: 10.1046/j.1523-1755.2002.00148.x. View

Schenk M, Zipfel A, Schulz C, Becker H, Viebahn R . RANTES in the postoperative course after liver transplantation. Transpl Int. 2000; 13 Suppl 1:S147-9. DOI: 10.1007/s001470050307. View

McDermott D, Zimmerman P, Guignard F, Kleeberger C, Leitman S, Murphy P . CCR5 promoter polymorphism and HIV-1 disease progression. Multicenter AIDS Cohort Study (MACS). Lancet. 1998; 352(9131):866-70. DOI: 10.1016/s0140-6736(98)04158-0. View

Shieh B, Liau Y, Hsieh P, Yan Y, Wang S, Li C . Influence of nucleotide polymorphisms in the CCR2 gene and the CCR5 promoter on the expression of cell surface CCR5 and CXCR4. Int Immunol. 2000; 12(9):1311-8. DOI: 10.1093/intimm/12.9.1311. View

Schroppel B, Fischereder M, Ashkar R, Lin M, Kramer B, Mardera B . The impact of polymorphisms in chemokine and chemokine receptors on outcomes in liver transplantation. Am J Transplant. 2002; 2(7):640-5. DOI: 10.1034/j.1600-6143.2002.20709.x. View

Abdi R, Huong T, Sahagun-Ruiz A, Murphy P, Brenner B, Milford E . Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation. J Am Soc Nephrol. 2002; 13(3):754-758. DOI: 10.1681/ASN.V133754. View

Goddard S, Williams A, Morland C, Qin S, Gladue R, Hubscher S . Differential expression of chemokines and chemokine receptors shapes the inflammatory response in rejecting human liver transplants. Transplantation. 2002; 72(12):1957-67. DOI: 10.1097/00007890-200112270-00016. View

Grandaliano G, Gesualdo L, Ranieri E, Monno R, Stallone G, Schena F . Monocyte chemotactic peptide-1 expression and monocyte infiltration in acute renal transplant rejection. Transplantation. 1997; 63(3):414-20. DOI: 10.1097/00007890-199702150-00015. View

10.

Szalai C, Duba J, Prohaszka Z, Kalina A , Szabo T, Nagy B . Involvement of polymorphisms in the chemokine system in the susceptibility for coronary artery disease (CAD). Coincidence of elevated Lp(a) and MCP-1 -2518 G/G genotype in CAD patients. Atherosclerosis. 2001; 158(1):233-9. DOI: 10.1016/s0021-9150(01)00423-3. View

11.

Akalin E, Murphy B . Gene polymorphisms and transplantation. Curr Opin Immunol. 2001; 13(5):572-6. DOI: 10.1016/s0952-7915(00)00261-2. View

12.

Segerer S, Cui Y, Eitner F, Goodpaster T, Hudkins K, Mack M . Expression of chemokines and chemokine receptors during human renal transplant rejection. Am J Kidney Dis. 2001; 37(3):518-31. View

13.

Gao W, Faia K, Csizmadia V, Smiley S, Soler D, King J . Beneficial effects of targeting CCR5 in allograft recipients. Transplantation. 2001; 72(7):1199-205. DOI: 10.1097/00007890-200110150-00003. View

14.

Al Sharif F, Ollier W, Hajeer A . A rare polymorphism at position -28 in the human RANTES promoter. Eur J Immunogenet. 1999; 26(5):373-4. DOI: 10.1046/j.1365-2370.1999.00162.x. View

15.

Grone H, Weber C, Weber K, Grone E, Rabelink T, Klier C . Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J. 1999; 13(11):1371-83. View

16.

Boring L, Gosling J, Cleary M, Charo I . Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature. 1998; 394(6696):894-7. DOI: 10.1038/29788. View

17.

Liu H, Chao D, Nakayama E, Taguchi H, Goto M, Xin X . Polymorphism in RANTES chemokine promoter affects HIV-1 disease progression. Proc Natl Acad Sci U S A. 1999; 96(8):4581-5. PMC: 16375. DOI: 10.1073/pnas.96.8.4581. View

18.

Rovin B, Lu L, Saxena R . A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression. Biochem Biophys Res Commun. 1999; 259(2):344-8. DOI: 10.1006/bbrc.1999.0796. View

19.

Fischereder M, Luckow B, Hocher B, Wuthrich R, Rothenpieler U, SCHNEEBERGER H . CC chemokine receptor 5 and renal-transplant survival. Lancet. 2001; 357(9270):1758-61. DOI: 10.1016/s0140-6736(00)04898-4. View

20.

Nelson P, Krensky A . Chemokines, chemokine receptors, and allograft rejection. Immunity. 2001; 14(4):377-86. DOI: 10.1016/s1074-7613(01)00118-2. View