High Molecular Weight Caldesmon Positive Stromal Cells in the Capsule of Thyroid Follicular Tumours and Tumour-like Lesions

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2002 Dec 4

PMID 12461057

Citations 1

Authors

H Nakayama

H Enzan

E Miyazaki

T Moriki

H Kiyoku

M Toi

N Kuroda

M Hiroi

Affiliations

Soon will be listed here.

Abstract

Aims: To investigate the smooth muscle nature of the spindle stromal cells in the capsule of thyroid tumours and tumour-like lesions.

Methods: Immunostaining for high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle differentiation, was performed in 70 primary thyroid tumours and tumour-like lesions (21 hyperplastic nodules, 29 follicular adenomas, five minimally invasive follicular carcinomas, six widely invasive follicular carcinomas, and nine encapsulated papillary carcinomas).

Results: HCD positive stromal cells (HCD+ cells) were detected in the capsule of 20 of the 21 hyperplastic nodules, and all of the 29 follicular adenomas and five minimally invasive follicular carcinomas, whereas HCD+ cells were seen in the capsule of only four of the six widely invasive follicular carcinomas and no HCD+ cells were seen in the capsule of the nine encapsulated papillary carcinomas examined.

Conclusions: The presence of HCD+ cells in the capsule is characteristic of thyroid follicular tumours and tumour-like lesions. The stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions are different from those of encapsulated papillary carcinoma.

Citing Articles

High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas.

Nakayama H, Enzan H, Yamamoto M, Miyazaki E, Yasui W J Clin Pathol. 2004; 57(7):776-7.

PMID: 15220377 PMC: 1770372. DOI: 10.1136/jcp.2004.016279.

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