Oncolytic Viruses

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2002 Dec 3

PMID 12459732

Citations 117

Authors

E Antonio Chiocca

Affiliations

Soon will be listed here.

Abstract

Although the cytotoxic effects of viruses are usually viewed in terms of pathogenicity, it is possible to harness this activity for therapeutic purposes. Viral genomes are highly versatile, and can be modified to direct their cytotoxicity towards cancer cells. These viruses are known as oncolytic viruses. How are viruses engineered to become tumour specific, and can they be used to safely treat cancer in humans?

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