Anandamide and Other N-acylethanolamines in Human Tumors

Overview

Journal Lipids

Specialty Biochemistry

Date 2002 Dec 3

PMID 12458627

Citations 20

Authors

Patricia C Schmid

Lester E Wold

Randy J Krebsbach

Evgueni V Berdyshev

Harald H O Schmid

Affiliations

Soon will be listed here.

Abstract

Long-chain N-acylethanolamines (NAE), including the endocannabinoid, anandamide, accumulate in mammalian tissues under a variety of pathological conditions. They have also been shown to inhibit the growth of various cancer cell lines in vitro. Here, we report the presence, in widely differing amounts (3.88-254.46 pmol/micromol lipid P), of NAE and their precursor phospholipids in various human tumors and some adjacent unaffected tissues. Anandamide ranged from 1.5 to 48% of total NAE, and incubation of tissue homogenates suggested possible NAE biosynthesis by both the established transacylation-phosphodiesterase pathway via N-acyl PE and by direct N-acylation of ethanolamine.

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