Phospholipase A2 Group IIA Expression in Gastric Adenocarcinoma is Associated with Prolonged Survival and Less Frequent Metastasis

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2002 Nov 29

PMID 12456890

Citations 54

Authors

Suet Y Leung

Xin Chen

Kent M Chu

Siu T Yuen

Jonathan Mathy

Jiafu Ji

Annie S Y Chan

Rui Li

Simon Law

Olga G Troyanskaya

I-Ping Tu

John Wong

Samuel So

David Botstein

Patrick O Brown

Affiliations

Soon will be listed here.

Abstract

We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

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