Mycobacterium Tuberculosis Transmission Between Cluster Members with Similar Fingerprint Patterns

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2002 Nov 28

PMID 12453352

Citations 13

Authors

Kashef Ijaz

Zhenhua Yang

H Stewart Matthews

Joseph H Bates

M Donald Cave

Affiliations

Soon will be listed here.

Abstract

Molecular epidemiologic studies provide evidence of transmission of Mycobacterium tuberculosis within clusters of patients whose isolates share identical IS6110-DNA fingerprint patterns. However, M. tuberculosis transmission among patients whose isolates have similar but not identical DNA fingerprint patterns (i.e., differing by a single band) has not been well documented. We used DNA fingerprinting, combined with conventional epidemiology, to show unsuspected patterns of tuberculosis transmission associated with three public bars in the same city. Among clustered TB cases, DNA fingerprinting analysis of isolates with similar and identical fingerprints helped us discover epidemiologic links missed during routine tuberculosis contact investigations.

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References

Yang Z, Chaves F, Barnes P, Burman W, Koehler J, Eisenach K . Evaluation of method for secondary DNA typing of Mycobacterium tuberculosis with pTBN12 in epidemiologic study of tuberculosis. J Clin Microbiol. 1996; 34(12):3044-8. PMC: 229457. DOI: 10.1128/jcm.34.12.3044-3048.1996. View

Chaves F, Yang Z, Hajj H, Alonso M, Burman W, Eisenach K . Usefulness of the secondary probe pTBN12 in DNA fingerprinting of Mycobacterium tuberculosis. J Clin Microbiol. 1996; 34(5):1118-23. PMC: 228966. DOI: 10.1128/jcm.34.5.1118-1123.1996. View

Barnes P, Yang Z, Preston-Martin S, Pogoda J, Jones B, Otaya M . Patterns of tuberculosis transmission in Central Los Angeles. JAMA. 1997; 278(14):1159-63. View

Yaganehdoost A, Graviss E, Ross M, Adams G, Ramaswamy S, Wanger A . Complex transmission dynamics of clonally related virulent Mycobacterium tuberculosis associated with barhopping by predominantly human immunodeficiency virus-positive gay men. J Infect Dis. 1999; 180(4):1245-51. DOI: 10.1086/314991. View

van Soolingen D, Hermans P, de Haas P, Soll D, van Embden J . Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis. J Clin Microbiol. 1991; 29(11):2578-86. PMC: 270376. DOI: 10.1128/jcm.29.11.2578-2586.1991. View

Edlin B, Tokars J, GRIECO M, Crawford J, Williams J, Sordillo E . An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome. N Engl J Med. 1992; 326(23):1514-21. DOI: 10.1056/NEJM199206043262302. View

Rastogi N, Ross B, Dwyer B, Goh K, Jeantils V, Cruaud P . Emergence during unsuccessful chemotherapy of multiple drug resistance in a strain of Mycobacterium tuberculosis. Eur J Clin Microbiol Infect Dis. 1992; 11(10):901-7. DOI: 10.1007/BF01962370. View

Small P, Shafer R, Hopewell P, Singh S, Murphy M, Desmond E . Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection. N Engl J Med. 1993; 328(16):1137-44. DOI: 10.1056/NEJM199304223281601. View

Yuen L, Ross B, Jackson K, Dwyer B . Characterization of Mycobacterium tuberculosis strains from Vietnamese patients by Southern blot hybridization. J Clin Microbiol. 1993; 31(6):1615-8. PMC: 265589. DOI: 10.1128/jcm.31.6.1615-1618.1993. View

10.

van Soolingen D, de Haas P, Hermans P, Groenen P, van Embden J . Comparison of various repetitive DNA elements as genetic markers for strain differentiation and epidemiology of Mycobacterium tuberculosis. J Clin Microbiol. 1993; 31(8):1987-95. PMC: 265684. DOI: 10.1128/jcm.31.8.1987-1995.1993. View

11.

Tabet S, Goldbaum G, Hooton T, Eisenach K, Cave M, Nolan C . Restriction fragment length polymorphism analysis detecting a community-based tuberculosis outbreak among persons infected with human immunodeficiency virus. J Infect Dis. 1994; 169(1):189-92. DOI: 10.1093/infdis/169.1.189. View

12.

Cave M, Eisenach K, Templeton G, Salfinger M, Mazurek G, Bates J . Stability of DNA fingerprint pattern produced with IS6110 in strains of Mycobacterium tuberculosis. J Clin Microbiol. 1994; 32(1):262-6. PMC: 263014. DOI: 10.1128/jcm.32.1.262-266.1994. View

13.

Small P, Hopewell P, Singh S, Paz A, Parsonnet J, Ruston D . The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods. N Engl J Med. 1994; 330(24):1703-9. DOI: 10.1056/NEJM199406163302402. View

14.

Fitzpatrick L, Hardacker J, Heirendt W, Agerton T, Streicher A, Melnyk H . A preventable outbreak of tuberculosis investigated through an intricate social network. Clin Infect Dis. 2001; 33(11):1801-6. DOI: 10.1086/323671. View

15.

Alland D, Kalkut G, Moss A, McAdam R, Hahn J, Bosworth W . Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods. N Engl J Med. 1994; 330(24):1710-6. DOI: 10.1056/NEJM199406163302403. View

16.

Kline S, Hedemark L, Davies S . Outbreak of tuberculosis among regular patrons of a neighborhood bar. N Engl J Med. 1995; 333(4):222-7. DOI: 10.1056/NEJM199507273330404. View

17.

Burman W, Reves R, Hawkes A, Rietmeijer C, Yang Z, El-Hajj H . DNA fingerprinting with two probes decreases clustering of Mycobacterium tuberculosis. Am J Respir Crit Care Med. 1997; 155(3):1140-6. DOI: 10.1164/ajrccm.155.3.9117000. View