Tryptophans 286 and 288 in the C-terminal Region of Protein B23.1 Are Important for Its Nucleolar Localization

Overview

Journal Biosci Biotechnol Biochem

Publisher Oxford University Press

Specialties Biochemistry
Biotechnology

Date 2002 Nov 27

PMID 12450141

Citations 34

Authors

Yuki Nishimura

Takeshi Ohkubo

Yukio Furuichi

Hayato Umekawa

Affiliations

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Abstract

Nucleolar protein B23 can shuttle between the nucleolus and cytoplasm. However, the mechanism involved in the protein moving and staying in the nucleolus is not fully understood. To identify the nucleolar localization signal sequence of protein B23, we examined the subnuclear location of B23.1 mutant proteins fused with green fluorescent protein in HeLa cells. The results suggested that the two C-terminal tryptophan residues (Trp-286 and Trp-288) of protein B23.1 were important in this phenomenon.

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