A New Class of RNA-binding Oligomers: Peptoid Amide and Ester Analogues

Overview

Journal Bioconjug Chem

Publisher American Chemical Society

Specialty Biochemistry

Date 2002 Nov 21

PMID 12440849

Citations 4

Authors

Venkitasamy Kesavan

Natarajan Tamilarasu

Hong Cao

Tariq M Rana

Affiliations

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Abstract

Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the trans-activation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all HIV mRNAs. Here we report the design, synthesis and in vitro activities of oligopeptoid amide and ester analogues which bind TAR RNA with high affinities. These results show that we have identified a new class of unnatural oligomers for RNA targeting.

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