Sleep and Sleep Homeostasis in Mice Lacking the 5-HT2c Receptor

Overview

Journal Neuropsychopharmacology

Date 2002 Nov 15

PMID 12431861

Citations 32

Authors

Marcos G Frank

Michael P Stryker

Laurence H Tecott

Affiliations

Soon will be listed here.

Abstract

Studies in humans and rats indicate that serotonin (5-hydroxytryptamine, 5-HT) receptors are involved in mammalian sleep expression. We investigated the contribution of the 5-HT2c receptor to sleep expression by examining sleep patterns in mice bearing a targeted null mutation of this receptor. 5-HT2c receptor knock-out mice had more wakefulness, several abnormalities in rapid eye movement sleep expression and an enhanced response to sleep deprivation compared with wild-type control mice. These findings suggest that 5HT2c receptors may mediate several effects on sleep that have been ascribed to serotonin.

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