A Novel Silver(i)-mediated DNA Base Pair

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2002 Nov 15

PMID 12431092

Citations 17

Authors

Nicole Zimmermann

Eric Meggers

Peter G Schultz

Affiliations

Soon will be listed here.

Abstract

We have generated a novel silver(I)-mediated unnatural DNA base pair consisting of two 2,6-bis(ethylthiomethyl)pyridine nucleobases SPy. This metallo-base pair has a remarkably high pairing stability and selectivity which rivals that of the natural base pairs dA:dT and dC:dG. UV-melting experiments revealed that the dSPy:dSPy self-pair can replace natural base pairs at multiple sites and still form stable DNA duplexes.

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