Nocturnal Leg Cramps in Older People
Overview
Authors
Affiliations
Nocturnal leg cramps are common in older people. Such cramps are associated with many common diseases and medications. Physiological methods may be useful for preventing cramps in some people, but there have been no controlled trials of these approaches. Quinine is moderately effective in preventing nocturnal leg cramps. However, there are concerns about the risk/benefit ratio with this drug. In patients with severe symptoms, a trial of 4-6 weeks' treatment with quinine is probably still justified, but the efficacy of treatment should be monitored, for example using a sleep and cramp diary.
Nocturnal Leg Cramps and Lumbar Spinal Stenosis: A Cross-Sectional Study in the Community.
Handa J, Otani K, Nikaido T, Kikuchi S, Konno S Int J Gen Med. 2022; 15:7985-7993.
PMID: 36345529 PMC: 9636894. DOI: 10.2147/IJGM.S383425.
Barna O, Lohoida P, Holovchenko Y, Bazylevych A, Velychko V, Hovbakh I Nutr J. 2021; 20(1):90.
PMID: 34719399 PMC: 8559389. DOI: 10.1186/s12937-021-00747-9.
Non-drug therapies for the secondary prevention of lower limb muscle cramps.
Hawke F, Sadler S, Katzberg H, Pourkazemi F, Chuter V, Burns J Cochrane Database Syst Rev. 2021; 5:CD008496.
PMID: 33998664 PMC: 8127570. DOI: 10.1002/14651858.CD008496.pub3.
Lamberti N, Lopez-Soto P, Rodriguez-Borrego M, Straudi S, Basaglia N, Zamboni P J Clin Med. 2019; 8(9).
PMID: 31500156 PMC: 6780675. DOI: 10.3390/jcm8091403.
Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial.
Roguin Maor N, Alperin M, Shturman E, Khairaldeen H, Friedman M, Karkabi K JAMA Intern Med. 2017; 177(5):617-623.
PMID: 28241153 PMC: 5818780. DOI: 10.1001/jamainternmed.2016.9261.