Inhibition of Polyomavirus Ori-dependent DNA Replication by MSin3B

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2002 Nov 5

PMID 12414923

Citations 2

Authors

An-Yong Xie

William R Folk

Affiliations

Soon will be listed here.

Abstract

When tethered in cis to DNA, the transcriptional corepressor mSin3B inhibits polyomavirus (Py) ori-dependent DNA replication in vivo. Histone deacetylases (HDACs) appear not to be involved, since tethering class I and class II HDACs in cis does not inhibit replication and treating the cells with trichostatin A does not specifically relieve inhibition by mSin3B. However, the mSin3B L59P mutation that impairs mSin3B interaction with N-CoR/SMRT abrogates inhibition of replication, suggesting the involvement of N-CoR/SMRT. Py large T antigen interacts with mSin3B, suggesting an HDAC-independent mechanism by which mSin3B inhibits DNA replication.

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