The Possible Role of Brain Histamine and H1 and H2 Receptors in the Development of Morphine Tolerance and Physical Dependence in Mice

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1975 Dec 1

PMID 1241224

Citations 9

Authors

C L Wong

M B Roberts

Affiliations

Soon will be listed here.

Abstract

The possible role of brain histamine in the mechanisms of morphine tolerance and physical dependence is under investigation in mice. L-histidine and histamine, given during the 'withdrawal' phase, significantly increase tolerance to the analgesic effects of morphine but reduce the degree of physical dependence. Metiamide significantly inhibits tolerance but has no consistent effect on physical dependence. These results suggest that H2 receptors may be involved in the development of morphine tolerance. Mepyramine does not significantly affect tolerance, and with regard to dependence there is an effect only on body weight loss, which is increased. However, combined treatment with metiamide and mepyramine inhibits tolerance significantly more than metiamide alone; and withdrawal jumping is also reduced more significantly by combined treatment than by the separate administration of these drugs. It is suggested that brain histamine is definitely implicated in the mechanisms of the 'withdrawal' phase of morphine tolerance and physical dependence in mice, with H2 receptors probably playing the more important part.

Citing Articles

Palonosetron and hydroxyzine pre-treatment reduces the objective signs of experimentally-induced acute opioid withdrawal in humans: a double-blinded, randomized, placebo-controlled crossover study.

Erlendson M, DArcy N, Encisco E, Yu J, Rincon-Cruz L, Peltz G Am J Drug Alcohol Abuse. 2016; 43(1):78-86.

PMID: 27712113 PMC: 5728104. DOI: 10.1080/00952990.2016.1210614.

Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation.

Vanhanen J, Nuutinen S, Lintunen M, Maki T, Ramo J, Karlstedt K Br J Pharmacol. 2013; 170(1):177-87.

PMID: 23489295 PMC: 3764859. DOI: 10.1111/bph.12170.

Effects of antihistaminics on naloxone-induced withdrawal in morphine-dependent mice.

Leza J, Lizasoain I, Lorenzo P Psychopharmacology (Berl). 1990; 102(1):106-11.

PMID: 1975446 DOI: 10.1007/BF02245753.

The effect of thiazol-4-yimethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice.

Hui K Experientia. 1976; 32(10):1313-5.

PMID: 987927 DOI: 10.1007/BF01953112.

The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.

Wong C, Roberts M Agents Actions. 1976; 6(5):569-76.

PMID: 987696 DOI: 10.1007/BF01971571.

References

Marshall I, Weinstock M . A quantitative method for the assessment of physical dependence on narcotic analgesics in mice. Br J Pharmacol. 1969; 37(2):505P-506P. PMC: 1703702. View

Frumkin K . Physical dependence in rats after low morphine doses. Life Sci. 1974; 15(3):455-62. DOI: 10.1016/0024-3205(74)90343-9. View

Black J, Duncan W, Durant C, Ganellin C, Parsons E . Definition and antagonism of histamine H 2 -receptors. Nature. 1972; 236(5347):385-90. DOI: 10.1038/236385a0. View

Hui K, Roberts M . An improved implantation pellet for rapid induction of morphine dependence in mice. J Pharm Pharmacol. 1975; 27(8):569-73. DOI: 10.1111/j.2042-7158.1975.tb09508.x. View

WAY E, Loh H, Shen F . Simultaneous quantitative assessment of morphine tolerance and physical dependence. J Pharmacol Exp Ther. 1969; 167(1):1-8. View

Wei E, Loh H, WAY E . Quantitative aspects of precipitated abstinence in morphine-dependent rats. J Pharmacol Exp Ther. 1973; 184(2):398-403. View

Mudgill L, Friedhoff A, Tobey J . Effect of intraventricular administrations of epinephrine, norepinephrine, dopamine, acetylcholine and physostigmine on morphine analgesia in mice. Arch Int Pharmacodyn Ther. 1974; 210(1):85-91. View

Kamei C, Ueki S . Naloxone-induced abstinence syndromes in morphine-treated mice. Jpn J Pharmacol. 1974; 24(4):655-7. DOI: 10.1254/jjp.24.655. View

Nahorski S, Rogers K, Smith B . Histamine H2 receptors and cyclic AMP in brain. Life Sci. 1974; 15(11):1887-94. DOI: 10.1016/0024-3205(74)90039-3. View

10.

Green J . HISTAMINE AND THE NERVOUS SYSTEM. Fed Proc. 1964; 23:1095-102. View

11.

COLLIER H, Francis D, Schneider C . Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation. Nature. 1972; 237(5352):220-3. DOI: 10.1038/237220a0. View

12.

Baudry M, Martres M, Schwartz J . H1 and H2 receptors in the histamine-induced accumulation of cyclic AMP in guinea pig brain slices. Nature. 1975; 253(5490):362-4. DOI: 10.1038/253362a0. View

13.

Gorlitz B, Frey H . Central monoamines and antinociceptive drug action. Eur J Pharmacol. 1972; 20(2):171-80. DOI: 10.1016/0014-2999(72)90146-x. View

14.

HANO K, Kaneto H, KAKUNAGA T, MORIBAYASHI N . PHARMACOLOGICAL STUDIES OF ANALGESICS--VI. THE ADMINISTRATION OF MORPHINE AND CHANGES IN ACETYLCHOLINE METABOLISM MOUSE BRAIN. Biochem Pharmacol. 1964; 13:441-7. DOI: 10.1016/0006-2952(64)90164-9. View

15.

Francis D, Schneider C . Jumping after naloxone precipitated withdrawal of chronic morphine in the rat. Br J Pharmacol. 1971; 41(2):424P-425P. PMC: 1703263. View

16.

GRUMBACH L, Shelofsky M, Boston Jr J . The kinetics of physical dependence to morphine in the rat. Pharmacology. 1974; 11(1):38-51. DOI: 10.1159/000136465. View

17.

Taylor K, Snyder S . Dynamics of the regulation of histamine levels in mouse brain. J Neurochem. 1972; 19(2):341-54. DOI: 10.1111/j.1471-4159.1972.tb01344.x. View