Synthesis of the Eight Enantiomerically Pure Diastereomers of the 12-F(2)-isoprostanes

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2002 Oct 31

PMID 12405840

Citations 6

Authors

Douglass F Taber

Ming Xu

John C Hartnett

Affiliations

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Abstract

Syntheses of the eight enantiomerically pure diastereomers of the 12-F(2)-isoprostanes (4-11) are described. The key steps included rhodium-mediated intramolecular cyclopropanation and enzymatic resolution of the racemic diol 12.

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