Telomerase: a Target for Cancer Therapeutics

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2002 Oct 26

PMID 12398889

Citations 72

Authors

Jerry W Shay

Woodring E Wright

Affiliations

Soon will be listed here.

Abstract

The continuous growth of advanced malignancies almost universally correlates with the reactivation of telomerase. While there is still a great deal of basic and applied research to be done, telomerase remains a very attractive novel target for cancer therapeutics. In this review, we will discuss the challenges and the pros and cons of the most promising antitelomerase approaches currently being investigated.

Citing Articles

Telomeres and telomerase in mesothelioma: Pathophysiology, biomarkers and emerging therapeutic strategies (Review).

Andreikos D, Spandidos D, Georgakopoulou V Int J Oncol. 2025; 66(3).

PMID: 39981889 PMC: 11844339. DOI: 10.3892/ijo.2025.5729.

A Phosphatidyl Conjugated Telomerase-Dependent Telomere-Targeting Nucleoside Demonstrates Colorectal Cancer Direct Killing and Immune Signaling.

Yilmaz M, Goksen S, Mender I, Esendagli G, Erdener S, Ahmed A Biomolecules. 2025; 14(12).

PMID: 39766323 PMC: 11674679. DOI: 10.3390/biom14121616.

Telomerase Inhibition by MST-312 Sensitizes Breast Cancer Cells to the Anti-cancer Properties of Plumbagin.

Sameni S, Viswanathan R, Ng G, Martinez-Lopez W, Hande M Genome Integr. 2024; 14:e20230002.

PMID: 38765717 PMC: 11102071. DOI: 10.14293/genint.14.1.003.

Combining old and new concepts in targeting telomerase for cancer therapy: transient, immediate, complete and combinatory attack (TICCA).

Ali J, Walter M Cancer Cell Int. 2023; 23(1):197.

PMID: 37679807 PMC: 10483736. DOI: 10.1186/s12935-023-03041-2.

Hyperpolarized δ-[1- C]gluconolactone imaging visualizes response to TERT or GABPB1 targeting therapy for glioblastoma.

Minami N, Hong D, Taglang C, Batsios G, Gillespie A, Viswanath P Sci Rep. 2023; 13(1):5190.

PMID: 36997627 PMC: 10063634. DOI: 10.1038/s41598-023-32463-1.