Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2002 Oct 25

PMID 12396099

Citations 17

Authors

Lizhen Chen

Xiang Gao

Affiliations

Soon will be listed here.

Abstract

Apoptosis is a conserved active cellular mechanism occurring under a range of physiological and pathological conditions. In the nervous system, apoptosis plays crucial roles in normal development and neuronal degenerating diseases. Various deleterious conditions, including accumulation of the mutant proteins in the endoplasmic reticulum (ER) and inhibition of ER to Golgi transport of proteins, may result in apoptosis. In this study, we examined the downstream events of apoptosis in differentiated PC 12 cells under ER stress induced by brefeldin A, an inhibitor of ER to Golgi protein transport. Activation of NF-kappaB and degradation of I-kappaB were observed within 2 hours, followed by up-regulation of GRP78 protein level in treated cells. Caspase-12 only appeared around 24 hours after brefeldin A treatment, coincident with cell nuclei fragmentation. These results suggest that neuronal apoptosis may be induced by ER stress through a NF-kappaB and caspase related pathway.

Citing Articles

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