Interleukin-8 and Growth-regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's Sarcoma

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2002 Oct 22

PMID 12388718

Citations 33

Authors

Brian R Lane

Jianguo Liu

Paul J Bock

Dominique Schols

Michael J Coffey

Robert M Strieter

Peter J Polverini

David M Markovitz

Affiliations

Soon will be listed here.

Abstract

The development of the complex neoplasm Kaposi's sarcoma is dependent on infection with the Kaposi's sarcoma-associated herpesvirus (KSHV) and appears to be greatly enhanced by cytokines and human immunodeficiency virus type 1 (HIV-1) Tat. Interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) are chemokines involved in chemoattraction, neovascularization, and stimulation of HIV-1 replication. We have previously demonstrated that production of GRO-alpha is stimulated by exposure of monocyte-derived macrophages (MDM) to HIV-1. Here we show that exposure of MDM to HIV-1, viral Tat, or viral gp120 leads to a substantial increase in IL-8 production. We also demonstrate that IL-8 and GRO-alpha are induced by KSHV infection of endothelial cells and are crucial to the angiogenic phenotype developed by KSHV-infected endothelial cells in cell culture and upon implantation into SCID mice. Thus, the three known etiological factors in Kaposi's sarcoma pathogenesis-KSHV, HIV-1 Tat, and cellular growth factors-might be linked, in part, through induction of IL-8 and GRO-alpha.

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References

Doranz B, Rucker J, Yi Y, Smyth R, Samson M, Peiper S . A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 1996; 85(7):1149-58. DOI: 10.1016/s0092-8674(00)81314-8. View

Alkhatib G, Combadiere C, Broder C, Feng Y, Kennedy P, Murphy P . CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science. 1996; 272(5270):1955-8. DOI: 10.1126/science.272.5270.1955. View

Hanahan D, Folkman J . Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996; 86(3):353-64. DOI: 10.1016/s0092-8674(00)80108-7. View

Schmidtmayerova H, Sherry B, Bukrinsky M . Chemokines and HIV replication. Nature. 1996; 382(6594):767. DOI: 10.1038/382767a0. View

Strathdee S, Veugelers P, Moore P . The epidemiology of HIV-associated Kaposi's sarcoma: the unraveling mystery. AIDS. 1996; 10 Suppl A:S51-7. View

Esser R, Glienke W, von Briesen H, Rubsamen-Waigmann H, Andreesen R . Differential regulation of proinflammatory and hematopoietic cytokines in human macrophages after infection with human immunodeficiency virus. Blood. 1996; 88(9):3474-81. View

Cornali E, Zietz C, Benelli R, Weninger W, Masiello L, Breier G . Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma. Am J Pathol. 1996; 149(6):1851-69. PMC: 1865351. View

Capobianchi M, Barresi C, Borghi P, Gessani S, Fantuzzi L, Ameglio F . Human immunodeficiency virus type 1 gp120 stimulates cytomegalovirus replication in monocytes: possible role of endogenous interleukin-8. J Virol. 1997; 71(2):1591-7. PMC: 191217. DOI: 10.1128/JVI.71.2.1591-1597.1997. View

Masood R, Cai J, Zheng T, Smith D, Naidu Y, Gill P . Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc Natl Acad Sci U S A. 1997; 94(3):979-84. PMC: 19625. DOI: 10.1073/pnas.94.3.979. View

10.

Bleul C, Fuhlbrigge R, Casasnovas J, Aiuti A, Springer T . A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J Exp Med. 1996; 184(3):1101-9. PMC: 2192798. DOI: 10.1084/jem.184.3.1101. View

11.

Nakamura S, Rao N, Weich H, Rajeev B . Vascular endothelial growth factor is a potent angiogenic factor in AIDS-associated Kaposi's sarcoma-derived spindle cells. J Immunol. 1997; 158(10):4992-5001. View

12.

Coffey M, Woffendin C, Phare S, Strieter R, Markovitz D . RANTES inhibits HIV-1 replication in human peripheral blood monocytes and alveolar macrophages. Am J Physiol. 1997; 272(5 Pt 1):L1025-9. DOI: 10.1152/ajplung.1997.272.5.L1025. View

13.

Schols D, Este J, Henson G, De Clercq E . Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4. Antiviral Res. 1997; 35(3):147-56. DOI: 10.1016/s0166-3542(97)00025-9. View

14.

Kaufmann P, Heimrath S, Kim B, Mooney D . Highly porous polymer matrices as a three-dimensional culture system for hepatocytes. Cell Transplant. 1997; 6(5):463-8. DOI: 10.1177/096368979700600505. View

15.

Lafrenie R, Wahl L, Epstein J, Yamada K, Dhawan S . Activation of monocytes by HIV-Tat treatment is mediated by cytokine expression. J Immunol. 1997; 159(8):4077-83. View

16.

Davis C, Dikic I, Unutmaz D, Hill C, Arthos J, Siani M . Signal transduction due to HIV-1 envelope interactions with chemokine receptors CXCR4 or CCR5. J Exp Med. 1997; 186(10):1793-8. PMC: 2199136. DOI: 10.1084/jem.186.10.1793. View

17.

Yi Y, Rana S, Turner J, Gaddis N, Collman R . CXCR-4 is expressed by primary macrophages and supports CCR5-independent infection by dual-tropic but not T-tropic isolates of human immunodeficiency virus type 1. J Virol. 1998; 72(1):772-7. PMC: 109434. DOI: 10.1128/JVI.72.1.772-777.1998. View

18.

Fiorelli V, Gendelman R, Sirianni M, Chang H, Colombini S, Markham P . gamma-Interferon produced by CD8+ T cells infiltrating Kaposi's sarcoma induces spindle cells with angiogenic phenotype and synergy with human immunodeficiency virus-1 Tat protein: an immune response to human herpesvirus-8 infection?. Blood. 1998; 91(3):956-67. View

19.

Capobianchi M, Abbate I, Antonelli G, Turriziani O, Dolei A, Dianzani F . Inhibition of HIV type 1 BaL replication by MIP-1alpha, MIP-1beta, and RANTES in macrophages. AIDS Res Hum Retroviruses. 1998; 14(3):233-40. DOI: 10.1089/aid.1998.14.233. View

20.

Mocroft A, Youle M, Phillips A, Halai R, Easterbrook P, Johnson M . The incidence of AIDS-defining illnesses in 4883 patients with human immunodeficiency virus infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group. Arch Intern Med. 1998; 158(5):491-7. DOI: 10.1001/archinte.158.5.491. View