Step Conductance Increases in Bilayer Membranes Induced by Antibody-antigen-complement Action
Overview
Biophysics
Authors
Affiliations
A sharp rise in the electrical conductance of lipid bilayer membranes was observed following the addition of antigen (bovine serum), antibody (rabbit anti-bovine serum), and complement to the neighboring aqueous phases. At low concentrations, step increases in the conductivity occurred which are consistent with the appearance of about 2.2 nm holes in the membrane. Probably attack or lysis of the lipid bilayer by complement is responsible.
The use of antibody and complement to gain access to the interior of presynaptic nerve terminals.
Schweitzer E, Blaustein M Exp Brain Res. 1980; 38(4):443-53.
PMID: 7363977 DOI: 10.1007/BF00237525.
MULLER-EBERHARD H Springer Semin Immunopathol. 1984; 7(2-3):93-141.
PMID: 6387983 DOI: 10.1007/BF01893017.
Is the membrane attack complex of complement an enzyme?.
Boyle M Mol Cell Biochem. 1984; 61(1):5-15.
PMID: 6369113 DOI: 10.1007/BF00239603.
Single channel currents induced by complement in antibody-coated cell membranes.
Jackson M, Stephens C, Lecar H Proc Natl Acad Sci U S A. 1981; 78(10):6421-5.
PMID: 6273870 PMC: 349051. DOI: 10.1073/pnas.78.10.6421.
Benz R, Schmid A, Wiedmer T, Sims P J Membr Biol. 1986; 94(1):37-45.
PMID: 2433454 DOI: 10.1007/BF01901011.