Peroxynitrite in Myocardial Ischemia-reperfusion Injury

Overview

Journal Heart Fail Rev

Date 2002 Oct 16

PMID 12379821

Citations 15

Authors

Manoj M Lalu

Wenjie Wang

Richard Schulz

Affiliations

Soon will be listed here.

Abstract

Peroxynitrite is a highly reactive oxidant which is produced during reperfusion of the ischemic heart. The role that this molecule plays in reperfusion injury has been controversial. Many investigations have demonstrated toxic effects of peroxynitrite, whereas others have found it to be protective during reperfusion. This review surveys evidence supporting both sides and proposes that peroxynitrite is a dichotomous molecule with beneficial and detrimental effects on the reperfused heart. Its toxic effects are mediated by modification and activation of a variety of targets (including poly (ADP) ribose synthetase and matrix metalloproteinases) while its beneficial effects are primarily mediated through its reaction with thiols, resulting in the formation of NO donor compounds (S-nitrosothiols).

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References

Frears E, Zhang Z, Blake D, OConnell J, Winyard P . Inactivation of tissue inhibitor of metalloproteinase-1 by peroxynitrite. FEBS Lett. 1996; 381(1-2):21-4. DOI: 10.1016/0014-5793(96)00065-8. View

Schulz R, Panas D, Catena R, Moncada S, Olley P, Lopaschuk G . The role of nitric oxide in cardiac depression induced by interleukin-1 beta and tumour necrosis factor-alpha. Br J Pharmacol. 1995; 114(1):27-34. PMC: 1510184. DOI: 10.1111/j.1476-5381.1995.tb14901.x. View

Schulz R, Wambolt R . Inhibition of nitric oxide synthesis protects the isolated working rabbit heart from ischaemia-reperfusion injury. Cardiovasc Res. 1995; 30(3):432-9. View

Wang Q, Morcos E, Wiklund P, Pernow J . L-arginine enhances functional recovery and Ca(2+)-dependent nitric oxide synthase activity after ischemia and reperfusion in the rat heart. J Cardiovasc Pharmacol. 1997; 29(2):291-6. DOI: 10.1097/00005344-199702000-00020. View

Ischiropoulos H, Zhu L, Chen J, Tsai M, Martin J, Smith C . Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys. 1992; 298(2):431-7. DOI: 10.1016/0003-9861(92)90431-u. View

Peterson D, Asinger R, Elsperger K, Homans D, Eaton J . Reactive oxygen species may cause myocardial reperfusion injury. Biochem Biophys Res Commun. 1985; 127(1):87-93. DOI: 10.1016/s0006-291x(85)80129-7. View

de Miguel L, Arriero M, Farre J, Jimenez P, Garcia-Mendez A, De Frutos T . Nitric oxide production by neutrophils obtained from patients during acute coronary syndromes: expression of the nitric oxide synthase isoforms. J Am Coll Cardiol. 2002; 39(5):818-25. DOI: 10.1016/s0735-1097(01)01828-9. View

Uppu R, Squadrito G, Pryor W . Acceleration of peroxynitrite oxidations by carbon dioxide. Arch Biochem Biophys. 1996; 327(2):335-43. DOI: 10.1006/abbi.1996.0131. View

Xia Y, Tsai A, Berka V, Zweier J . Superoxide generation from endothelial nitric-oxide synthase. A Ca2+/calmodulin-dependent and tetrahydrobiopterin regulatory process. J Biol Chem. 1998; 273(40):25804-8. DOI: 10.1074/jbc.273.40.25804. View

10.

Beresewicz A, Lewartowski B . A protective role of nitric oxide in isolated ischaemic/reperfused rat heart. Cardiovasc Res. 1995; 30(6):1001-8. DOI: 10.1016/s0008-6363(95)00175-1. View

11.

Xia Y, Dawson V, Dawson T, Snyder S, Zweier J . Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A. 1996; 93(13):6770-4. PMC: 39102. DOI: 10.1073/pnas.93.13.6770. View

12.

Kooy N, Lewis S, Royall J, Ye Y, Kelly D, Beckman J . Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Crit Care Med. 1997; 25(5):812-9. DOI: 10.1097/00003246-199705000-00017. View

13.

Pasquet J, Zou M, Ullrich V . Peroxynitrite inhibition of nitric oxide synthases. Biochimie. 1996; 78(8-9):785-91. DOI: 10.1016/s0300-9084(97)82537-0. View

14.

Danielsen C, Wiggers H, Andersen H . Increased amounts of collagenase and gelatinase in porcine myocardium following ischemia and reperfusion. J Mol Cell Cardiol. 1998; 30(7):1431-42. DOI: 10.1006/jmcc.1998.0711. View

15.

Wu M, Pritchard Jr K, Kaminski P, Fayngersh R, Hintze T, Wolin M . Involvement of nitric oxide and nitrosothiols in relaxation of pulmonary arteries to peroxynitrite. Am J Physiol. 1994; 266(5 Pt 2):H2108-13. DOI: 10.1152/ajpheart.1994.266.5.H2108. View

16.

Quyyumi A, Dakak N, Andrews N, Gilligan D, Panza J, Cannon 3rd R . Contribution of nitric oxide to metabolic coronary vasodilation in the human heart. Circulation. 1995; 92(3):320-6. DOI: 10.1161/01.cir.92.3.320. View

17.

Brunner F, Leonhard B, Kukovetz W, Mayer B . Role of endothelin, nitric oxide and L-arginine release in ischaemia/reperfusion injury of rat heart. Cardiovasc Res. 1998; 36(1):60-6. DOI: 10.1016/s0008-6363(97)00138-7. View

18.

Lopaschuk G . Treating ischemic heart disease by pharmacologically improving cardiac energy metabolism. Am J Cardiol. 1998; 82(5A):14K-17K. DOI: 10.1016/s0002-9149(98)00532-3. View

19.

Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S . Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem. 1994; 269(42):26066-75. View

20.

Schulz R, Nava E, Moncada S . Induction and potential biological relevance of a Ca(2+)-independent nitric oxide synthase in the myocardium. Br J Pharmacol. 1992; 105(3):575-80. PMC: 1908438. DOI: 10.1111/j.1476-5381.1992.tb09021.x. View