Volumetric Measurement of the Hippocampus, the Anterior Cingulate Cortex, and the Retrosplenial Granular Cortex of the Rat Using Structural MRI

Overview

Journal Brain Res Brain Res Protoc

Specialty Neurology

Date 2002 Oct 16

PMID 12379436

Citations 17

Authors

O T Wolf

V Dyakin

C Vadasz

M J de Leon

B S McEwen

K Bulloch

Affiliations

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Abstract

MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.

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