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Volumetric Measurement of the Hippocampus, the Anterior Cingulate Cortex, and the Retrosplenial Granular Cortex of the Rat Using Structural MRI

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Specialty Neurology
Date 2002 Oct 16
PMID 12379436
Citations 17
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Abstract

MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.

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