The Influence of Varying Lengths of Glass and Asbestos Fibres on Tissue Response in Guinea Pigs

Overview

Journal Inhaled Part

Date 1975 Sep 1

PMID 1236235

Citations 12

Authors

G W Wright

M Kuschner

Affiliations

Soon will be listed here.

Abstract

Intratracheal injection of samples of naturally occurring and man-made mineral fibres into guinea pigs showed that while long fibre samples produced marked fibrosis, short fibre specimens produced only a macrophage reaction. In most cases the long fibre samples were administered in smaller doses than the short. The samples tested were crocidolite asbestos, a synthetic fluoramphibole and two specimens of glass fibre with different mean diameters. With all the minerals tested some short fibres, but not long fibres, were transported to the hilar lymph nodes. In some instances the numbers of short fibres found in these nodes appeared to be much higher than would be expected from the percentage of short fibres in the original sample, and it is suggested that this may be due to the breakdown of long fibres within the lung.

Citing Articles

Use of back-scatter electron signals to visualise cell/nanowires interactions in vitro and in vivo; frustrated phagocytosis of long fibres in macrophages and compartmentalisation in mesothelial cells in vivo.

Schinwald A, Donaldson K Part Fibre Toxicol. 2012; 9:34.

PMID: 22929371 PMC: 3724483. DOI: 10.1186/1743-8977-9-34.

Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura.

Murphy F, Poland C, Duffin R, Al-Jamal K, Ali-Boucetta H, Nunes A Am J Pathol. 2011; 178(6):2587-600.

PMID: 21641383 PMC: 3124020. DOI: 10.1016/j.ajpath.2011.02.040.

New perspectives on basic mechanisms in lung disease. 5. Respirable industrial fibres: mechanisms of pathogenicity.

Donaldson K, Brown R, Brown G Thorax. 1993; 48(4):390-5.

PMID: 8511739 PMC: 464440. DOI: 10.1136/thx.48.4.390.

Biopersistence of inhaled organic and inorganic fibers in the lungs of rats.

Warheit D, Hartsky M, Mchugh T, Kellar K Environ Health Perspect. 1994; 102 Suppl 5:151-7.

PMID: 7882921 PMC: 1567301. DOI: 10.1289/ehp.94102s5151.

Concentrations and dimensions of coated and uncoated asbestos fibres in the human lung.

Morgan A, Holmes A Br J Ind Med. 1980; 37(1):25-32.

PMID: 7370190 PMC: 1008641. DOI: 10.1136/oem.37.1.25.