In Search of Geographical Patterns in European Mitochondrial DNA

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 2002 Oct 2

PMID 12355353

Citations 38

Authors

Martin Richards

Vincent Macaulay

Antonio Torroni

Hans-Jurgen Bandelt

Affiliations

Soon will be listed here.

Abstract

Previous studies of mitochondrial DNA (mtDNA) in Europe and the Near East have suggested that, in contrast with classical markers and the Y chromosome, mtDNA does not exhibit significant geographical structuring. Here, we show that, with a sufficiently large sample size and a better resolved mtDNA tree, clades of mtDNA do indeed exhibit gradients similar to those of other marker systems. However, the more detailed analyses afforded by molecular sequence data suggest that the explanations for these gradients are likely to be much more complex than those proposed for classical markers.

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References

Wilson J, Weiss D, Richards M, Thomas M, Bradman N, Goldstein D . Genetic evidence for different male and female roles during cultural transitions in the British Isles. Proc Natl Acad Sci U S A. 2001; 98(9):5078-83. PMC: 33166. DOI: 10.1073/pnas.071036898. View

Finnila S, Lehtonen M, Majamaa K . Phylogenetic network for European mtDNA. Am J Hum Genet. 2001; 68(6):1475-84. PMC: 1226134. DOI: 10.1086/320591. View

Simoni L, Calafell F, Pettener D, Bertranpetit J, Barbujani G . Geographic patterns of mtDNA diversity in Europe. Am J Hum Genet. 2000; 66(1):262-78. PMC: 1288355. DOI: 10.1086/302706. View

Jobling M, Tyler-Smith C . New uses for new haplotypes the human Y chromosome, disease and selection. Trends Genet. 2000; 16(8):356-62. DOI: 10.1016/s0168-9525(00)02057-6. View

Helgason A, Hickey E, Goodacre S, Bosnes V, Stefansson K, WARD R . mtDna and the islands of the North Atlantic: estimating the proportions of Norse and Gaelic ancestry. Am J Hum Genet. 2001; 68(3):723-37. PMC: 1274484. DOI: 10.1086/318785. View

Torroni A, Bandelt H, DUrbano L, Lahermo P, Moral P, Sellitto D . mtDNA analysis reveals a major late Paleolithic population expansion from southwestern to northeastern Europe. Am J Hum Genet. 1998; 62(5):1137-52. PMC: 1377079. DOI: 10.1086/301822. View

MacEachern . Genes, Tribes, and African History. Curr Anthropol. 2000; 41(3):357-384. View

Semino O, Passarino G, Brega A, Fellous M, Santachiara-Benerecetti A . A view of the neolithic demic diffusion in Europe through two Y chromosome-specific markers. Am J Hum Genet. 1996; 59(4):964-8. PMC: 1914791. View

Semino O, Passarino G, Oefner P, Lin A, Arbuzova S, Beckman L . The genetic legacy of Paleolithic Homo sapiens sapiens in extant Europeans: a Y chromosome perspective. Science. 2000; 290(5494):1155-9. DOI: 10.1126/science.290.5494.1155. View

10.

Pfeiffer H, Brinkmann B, Huhne J, Rolf B, MORRIS A, Steighner R . Expanding the forensic German mitochondrial DNA control region database: genetic diversity as a function of sample size and microgeography. Int J Legal Med. 1999; 112(5):291-8. DOI: 10.1007/s004140050252. View

11.

Lutz S, Weisser H, Heizmann J, Pollak S . Location and frequency of polymorphic positions in the mtDNA control region of individuals from Germany. Int J Legal Med. 1998; 111(2):67-77. DOI: 10.1007/s004140050117. View

12.

Menozzi P, Piazza A, CAVALLI-SFORZA L . Synthetic maps of human gene frequencies in Europeans. Science. 1978; 201(4358):786-92. DOI: 10.1126/science.356262. View

13.

Cavalli-Sforza L, Minch E . Paleolithic and Neolithic lineages in the European mitochondrial gene pool. Am J Hum Genet. 1997; 61(1):247-54. PMC: 1715849. DOI: 10.1016/S0002-9297(07)64303-1. View

14.

Rosser Z, Zerjal T, Hurles M, Adojaan M, Alavantic D, Amorim A . Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. Am J Hum Genet. 2000; 67(6):1526-43. PMC: 1287948. DOI: 10.1086/316890. View

15.

Richards M, Macaulay V, Bandelt H, Sykes B . Phylogeography of mitochondrial DNA in western Europe. Ann Hum Genet. 1998; 62(Pt 3):241-60. DOI: 10.1046/j.1469-1809.1998.6230241.x. View

16.

. A nomenclature system for the tree of human Y-chromosomal binary haplogroups. Genome Res. 2002; 12(2):339-48. PMC: 155271. DOI: 10.1101/gr.217602. View

17.

Torroni A, Richards M, Macaulay V, Forster P, Villems R, Norby S . mtDNA haplogroups and frequency patterns in Europe. Am J Hum Genet. 2000; 66(3):1173-7. PMC: 1288155. DOI: 10.1086/302789. View

18.

Macaulay V, Richards M, Hickey E, Vega E, Cruciani F, Guida V . The emerging tree of West Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs. Am J Hum Genet. 1999; 64(1):232-49. PMC: 1377722. DOI: 10.1086/302204. View

19.

Sokal R, Harding R, Oden N . Spatial patterns of human gene frequencies in Europe. Am J Phys Anthropol. 1989; 80(3):267-94. DOI: 10.1002/ajpa.1330800302. View

20.

Torroni A, Bandelt H, Macaulay V, Richards M, Cruciani F, Rengo C . A signal, from human mtDNA, of postglacial recolonization in Europe. Am J Hum Genet. 2001; 69(4):844-52. PMC: 1226069. DOI: 10.1086/323485. View