The Acute Effects of Oral (--)-tryptophan in Human Subjects

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1975 Apr 1

PMID 1234498

Citations 22

Authors

M H Greenwood

M H Lader

B D Kantameneni

G Curzon

Affiliations

Soon will be listed here.

Abstract

1 The psychotropic effects of a single oral dose of (--)-tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self-ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.

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