Levamisole Treatment of Local and Metastatic Growth of Transplanted Rat Tumours

Overview

Journal Br J Cancer

Specialty Oncology

Date 1975 Sep 1

PMID 1233079

Citations 2

Authors

D G Hopper

M V Pimm

R W Baldwin

Affiliations

Soon will be listed here.

Abstract

Levamisole has been examined for its ability to control local growth and pulmonary metastases of transplanted rat tumours. The compound did not suppress subcutaneous growth of 3-methylcholanthrene induced sarcomata when administered systemically in a variety of regimens, or when injected in admixture with tumour cells. In addition, levamisole treatment failed to suppress pulmonary growth of intravenously transferred sarcoma cells or spontaneous pulmonary metastases appearing after surgical removal of a transplanted epithelioma.

Citing Articles

Ineffectiveness of levamisole as adjuvant to surgery with two lines of transplanted rat colonic carcinoma.

Martin M, Justrabo E, Martin F, Michel M, Leclerc A Br J Cancer. 1981; 44(3):464-6.

PMID: 7284241 PMC: 2010780. DOI: 10.1038/bjc.1981.207.

The growth and spontaneous dissemination of melanoma B16 and Lewis lung tumour in two sub-strains of C57BL/6J mice treated with Corynebacterium parvum and/or levamisole.

BOERYD B, Benktson A Clin Exp Metastasis. 1983; 1(3):289-95.

PMID: 6546203 DOI: 10.1007/BF00736411.

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