Article: Changes in thymus volume in adult HIV-infected patients under HAART: correlation with the T-cell repopulation

An important thymus role has been suggested in T-cell repopulation after HAART in adult HIV-1 infected patients. Thymus volume increase after treatment has been described in HIV-1 infected children but not in adult patients. The objective of this work was to evaluate the effect of HAART on the thymic volume of adult HIV-1 infected patients and its relation with the T-cell repopulation. Twenty-one adult patients following 24 weeks under HAART were included in the study. All patients underwent a thoracic computed tomography (CT) evaluation for the measurement of thymic volumes at weeks 0, 12 and 24. Baseline thymus volume showed a significant correlation with the patient's age. Thymic volume significantly increased after 24 weeks of HAART. Besides, a significant correlation between changes in the thymus volume and changes in both total and naïve CD4+ cell counts was found. Only patients with increases > or =100 CD4+ cell counts after treatment significantly increased the thymic volume. These data show the first evidence of an early change in thymic volume of adult HIV-1 infected patients under HAART. This increase was related to the rise of both total and naïve CD4+ cell counts suggesting a functional role of thymic volume increase.

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References

1.

Smith K, Valdez H, Landay A, Spritzler J, Kessler H, Connick E . Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis. 1999; 181(1):141-7. DOI: 10.1086/315169. View

2.

Franco J, Leal M, Pineda J, Macias J, Rubio A, Rey C . CD4+ and CD8+ T lymphocyte regeneration after anti-retroviral therapy in HIV-1-infected children and adult patients. Clin Exp Immunol. 2000; 119(3):493-8. PMC: 1905579. DOI: 10.1046/j.1365-2249.2000.01152.x. View

3.

Vigano A, Vella S, Saresella M, Vanzulli A, Bricalli D, Di Fabio S . Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume. AIDS. 2000; 14(3):251-61. DOI: 10.1097/00002030-200002180-00007. View

4.

Choyke P, Zeman R, Gootenberg J, Greenberg J, Hoffer F, Frank J . Thymic atrophy and regrowth in response to chemotherapy: CT evaluation. AJR Am J Roentgenol. 1987; 149(2):269-72. DOI: 10.2214/ajr.149.2.269. View

5.

McCune J . Thymic function in HIV-1 disease. Semin Immunol. 1998; 9(6):397-404. DOI: 10.1006/smim.1997.0098. View

6.

Zhang L, Lewin S, Markowitz M, Lin H, Skulsky E, Karanicolas R . Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy. J Exp Med. 1999; 190(5):725-32. PMC: 2195623. DOI: 10.1084/jem.190.5.725. View

7.

Walker R, Carter C, Muul L, Natarajan V, Herpin B, Leitman S . Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults. Nat Med. 1998; 4(7):852-6. DOI: 10.1038/nm0798-852. View

8.

Douek D, McFarland R, KEISER P, Gage E, Massey J, Haynes B . Changes in thymic function with age and during the treatment of HIV infection. Nature. 1999; 396(6712):690-5. DOI: 10.1038/25374. View

9.

Haynes B, Hale L, Weinhold K, Patel D, Liao H, Bressler P . Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection. J Clin Invest. 1999; 103(4):453-60. PMC: 408098. DOI: 10.1172/JCI5201. View

10.

Bucy R, Hockett R, Derdeyn C, Saag M, Squires K, Sillers M . Initial increase in blood CD4(+) lymphocytes after HIV antiretroviral therapy reflects redistribution from lymphoid tissues. J Clin Invest. 1999; 103(10):1391-8. PMC: 408455. DOI: 10.1172/JCI5863. View

11.

McCune J, Loftus R, Schmidt D, Carroll P, Webster D, Francis I . High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 1998; 101(11):2301-8. PMC: 508819. DOI: 10.1172/JCI2834. View

Changes in Thymus Volume in Adult HIV-infected Patients Under HAART: Correlation with the T-cell Repopulation