Age-related Changes in the Proportion of Intracranial Cerebrospinal Fluid Space Measured Using Volumetric Computerized Tomography Scanning

Overview

Journal J Neurosurg

Specialty Neurosurgery

Date 2002 Sep 26

PMID 12296645

Citations 9

Authors

Hiroshi Wanifuchi

Takashi Shimizu

Takashi Maruyama

Affiliations

Soon will be listed here.

Abstract

Object: The purpose of this study was to establish a standard curve to demonstrate normal age-related changes in the proportion of intracranial cerebrospinal fluid (CSF) space in intracranial volume (ICV) during each decade of life.

Methods: Using volumetric computerized tomography (CT) scanning and computer-guided volume measurement software, ICV and cerebral parenchymal volume (CPV) for each decade of life were measured and the intracranial CSF ratio was calculated by the following formula: percentage of CSF = (ICV - CPV)/ICV x 100%. The standard curve for age-related changes in normal percentages of intracranial CSF was obtained.

Conclusions: Based on this standard curve, the percentage of intracranial CSF rapidly increased after the sixth decade, seeming to reflect the brain atrophy that accompanies increased age.

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