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Incorporation of a Novel Nucleobase Allows Stable Oligonucleotide-directed Triple Helix Formation at the Target Sequence Containing a Purine.pyrimidine Interruption

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Specialty Chemistry
Date 2002 Sep 21
PMID 12240328
Citations 13
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Abstract

Thermal denaturation experiments have established that an oligonucleotide incorporating the artificial nucleobase S, does form a stable triplex with a double stranded DNA which exhibits a pyrimidine interruption within the oligopurine sequence.

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