Comparison of Automated and Manual MRI Volumetry of Hippocampus in Normal Aging and Dementia

Overview

Journal J Magn Reson Imaging

Date 2002 Sep 3

PMID 12205587

Citations 107

Authors

Yuan-Yu Hsu

Norbert Schuff

An-Tao Du

Kevin Mark

Xiaoping Zhu

Dawn Hardin

Michael W Weiner

Affiliations

Soon will be listed here.

Abstract

Purpose: To determine whether automatic and manual measurements of hippocampal volume differences on MRI between normal aging, cognitive impairment (CI), and Alzheimer's disease (AD) yield similar results.

Materials And Methods: Reliability was determined for an automatic and a manual method on nine volunteers (22-83 years old) who underwent MRI twice in 1 day. Hippocampal volumes of 20 cognitively normal subjects (mean age 74.0 +/- 6.2 years) and age-matched patients (20 CI and 20 AD) were compared.

Results: The intraclass correlation for automatic calculations of hippocampal volume was 0.94; for manual tracing it was 0.99. Volume differences between cognitively normal, CI, and AD subjects from the automatic and manual methods were similar.

Conclusion: Because the automatic calculations were faster and less susceptible to rater bias than manual tracing, this automated method is expected to be very useful for analyzing hippocampal changes in studies of aging and dementia.

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