Antimycobacterial Physalins from Physalis Angulata L. (Solanaceae)

Overview

Journal Phytother Res

Publisher Wiley

Date 2002 Aug 31

PMID 12203265

Citations 18

Authors

A H Januario

E Rodrigues Filho

R C L R Pietro

S Kashima

D N Sato

S C Franca

Affiliations

Soon will be listed here.

Abstract

Crude extracts and fractions from aerial parts of Physalis angulata have been bioassayed for antimycobacterial activity. Fraction A1-29-12 containing physalins B, F and D exhibited a minimum inhibitory concentration value (MIC) against Mycobacterium tuberculosis H(37)Rv strain of 32 microg/mL. Purified physalin B and physalin D were also tested showing MIC values against Mycobacterium tuberculosis H(37)Rv strain of > 128 microg/mL and 32 microg/mL respectively, suggesting that physalin D plays a relevant role in the antimycobacterial activity displayed. Structural elucidation of both physalins D and B was based on detailed (13)C and (1)H NMR spectral analysis with the aid of 2D-correlation spectroscopy ((1)H-(1)H, COSY, HSQC and HMBC). The assignment of the (13)C chemical shift for physalin D is reported here for the first time.

Citing Articles

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Rusakov Y, Semenov V, Rusakova I Int J Mol Sci. 2024; 25(19).

PMID: 39408918 PMC: 11477434. DOI: 10.3390/ijms251910588.

Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of by binding to AgrA.

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On the Efficiency of the Density Functional Theory (DFT)-Based Computational Protocol for H and C Nuclear Magnetic Resonance (NMR) Chemical Shifts of Natural Products: Studying the Accuracy of the pecS- ( = 1, 2) Basis Sets.

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A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins.

Manome T, Hara Y, Ishibashi M J Nat Med. 2022; 77(2):370-378.

PMID: 36495388 DOI: 10.1007/s11418-022-01670-x.