Effect of Vagotomy on Secretin Release in Man

Overview

Journal Gut

Specialty Gastroenterology

Date 1975 Dec 1

PMID 1218818

Citations 6

Authors

A S Ward

S R Bloom

Affiliations

Soon will be listed here.

Abstract

The release of secretin by intraduodenal acid has been measured by means of a highly sensitive radioimmunoassay in 12 normal subjects, 23 duodenal ulcer patients, and 14 vagotomized patients (6 TV + P; 4 SV + P;4 HSV). A highly significant response occurred in all three groups. There was no significant difference between the groups either in the magnitude or timing of this response, though the absolute values for pre-stimulation and peak secretin were significantly smaller in preoperative duodenal ulcer patients than in either the normal subjects or the vagotomized patients. The secretin response was similar after truncal, selective, and highly selective vagotomy. These results suggest that secretin release is not dependent on intact vagal innervation of the small intestine in man.

Citing Articles

Duodenal ulcer: does pathophysiology equal aetiology?.

Wormsley K Gut. 1983; 24(9):775-80.

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Radioimmunoassay of secretin. A critical review and current status.

Chang T, Chey W Dig Dis Sci. 1980; 25(7):529-52.

PMID: 6104568 DOI: 10.1007/BF01315215.

Plasma secretin and pancreatic bicarbonate response to exogenous secretin in man.

Hacki W, Bloom S, Mitznegg P, Domschke W, Domschke S, Belohlavek D Gut. 1977; 18(3):191-5.

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Role of neural influences in the release of gastrin, glucagon, and secretin during hypoglycaemia in man.

McLoughlin J, Hayes J, Buchanan K, Kelly J Gut. 1978; 19(7):632-9.

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Effect of vagotomy on gastrointestinal hormones.

Becker H, Borger H, Schafmayer A World J Surg. 1979; 3(5):615-22.

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