Bacterial Pneumonia Can Increase Serum Concentration of Clozapine

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 2002 Aug 20

PMID 12185555

Citations 18

Authors

K Raaska

V Raitasuo

M Arstila

P J Neuvonen

Affiliations

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Abstract

Concentrations of serum clozapine, C-reactive protein (CRP) and alpha1 acid glycoprotein were greatly increased during a bacterial pneumonia in a 53-year-old woman. As the pneumonia subsided, and CRP and alpha1 acid glycoprotein normalised, serum clozapine concentration also decreased to the previous level. An increased serum clozapine and a lowered N-desmethylclozapine to clozapine ratio during the infection suggest a decreased cytochrome P(450) (CYP)1A2 activity. Cytokine-mediated CYP1A2 suppression is discussed.

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