Yersinia High-pathogenicity Island Contributes to Virulence in Escherichia Coli Causing Extraintestinal Infections

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2002 Aug 17

PMID 12183596

Citations 59

Authors

Soren Schubert

Bertrand Picard

Stephanie Gouriou

Jurgen Heesemann

Erick Denamur

Affiliations

Soon will be listed here.

Abstract

The Yersinia high-pathogenicity island (HPI) encodes an iron uptake system mediated by the siderophore yersiniabactin (Ybt) and confers the virulence of highly pathogenic Yersinia species. This HPI is also widely distributed in human pathogenic members of the family of Enterobacteriaceae, above all in extraintestinal pathogenic Escherichia coli (ExPEC). In the present study we demonstrate a highly significant correlation of a functional HPI and extraintestinal virulence in E. coli. Moreover, using a mouse infection model, we show for the first time that the HPI contributes to the virulence of ExPEC.

Citing Articles

Escherichia coli HPI-induced duodenitis through ubiquitin regulation of the TLR4/NF-κB pathway.

Zhao J, Yang W, Gao B, Wang H, Chen L, Shan C BMC Vet Res. 2025; 21(1):66.

PMID: 39953596 PMC: 11829554. DOI: 10.1186/s12917-025-04515-3.

Canine uropathogenic and avian pathogenic Escherichia coli harboring conjugative plasmids exhibit augmented growth and exopolysaccharide production in response to Enterococcus faecalis.

Walker G, Suyemoto M, Jacob M, Thakur S, Borst L PLoS One. 2024; 19(11):e0312732.

PMID: 39602363 PMC: 11602052. DOI: 10.1371/journal.pone.0312732.

The transcriptional regulation of the horizontally acquired iron uptake system, yersiniabactin and its contribution to oxidative stress tolerance and pathogenicity of globally emerging strains.

Diamant I, Adani B, Sylman M, Rahav G, Gal-Mor O Gut Microbes. 2024; 16(1):2369339.

PMID: 38962965 PMC: 11225919. DOI: 10.1080/19490976.2024.2369339.

Emergence of Poultry-Associated Human Salmonella enterica Serovar Abortusovis Infections, New South Wales, Australia.

Payne M, Williamson S, Wang Q, Zhang X, Sintchenko V, Pavic A Emerg Infect Dis. 2024; 30(4):691-700.

PMID: 38526124 PMC: 10977856. DOI: 10.3201/eid3004.230958.

microbeMASST: a taxonomically informed mass spectrometry search tool for microbial metabolomics data.

Zuffa S, Schmid R, Bauermeister A, Gomes P, Caraballo-Rodriguez A, Abiead Y Nat Microbiol. 2024; 9(2):336-345.

PMID: 38316926 PMC: 10847041. DOI: 10.1038/s41564-023-01575-9.

References

Fetherston J, Bearden S, Perry R . YbtA, an AraC-type regulator of the Yersinia pestis pesticin/yersiniabactin receptor. Mol Microbiol. 1996; 22(2):315-25. DOI: 10.1046/j.1365-2958.1996.00118.x. View

Autenrieth I, Hantke K, Heesemann J . Immunosuppression of the host and delivery of iron to the pathogen: a possible dual role of siderophores in the pathogenesis of microbial infections?. Med Microbiol Immunol. 1991; 180(3):135-41. DOI: 10.1007/BF00206117. View

Pelludat C, Rakin A, Jacobi C, Schubert S, Heesemann J . The yersiniabactin biosynthetic gene cluster of Yersinia enterocolitica: organization and siderophore-dependent regulation. J Bacteriol. 1998; 180(3):538-46. PMC: 106919. DOI: 10.1128/JB.180.3.538-546.1998. View

Boyd E, Hartl D . Chromosomal regions specific to pathogenic isolates of Escherichia coli have a phylogenetically clustered distribution. J Bacteriol. 1998; 180(5):1159-65. PMC: 107003. DOI: 10.1128/JB.180.5.1159-1165.1998. View

Bingen E, Picard B, Brahimi N, Mathy S, Desjardins P, Elion J . Phylogenetic analysis of Escherichia coli strains causing neonatal meningitis suggests horizontal gene transfer from a predominant pool of highly virulent B2 group strains. J Infect Dis. 1998; 177(3):642-50. DOI: 10.1086/514217. View

Lecointre G, Rachdi L, Darlu P, Denamur E . Escherichia coli molecular phylogeny using the incongruence length difference test. Mol Biol Evol. 1998; 15(12):1685-95. DOI: 10.1093/oxfordjournals.molbev.a025895. View

Picard B, Garcia J, Gouriou S, Duriez P, Brahimi N, Bingen E . The link between phylogeny and virulence in Escherichia coli extraintestinal infection. Infect Immun. 1999; 67(2):546-53. PMC: 96353. DOI: 10.1128/IAI.67.2.546-553.1999. View

Perry R, Balbo P, Jones H, Fetherston J, DeMoll E . Yersiniabactin from Yersinia pestis: biochemical characterization of the siderophore and its role in iron transport and regulation. Microbiology (Reading). 1999; 145 ( Pt 5):1181-1190. DOI: 10.1099/13500872-145-5-1181. View

Johnson J, Stell A . Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J Infect Dis. 1999; 181(1):261-72. DOI: 10.1086/315217. View

10.

Carniel E . The Yersinia high-pathogenicity island. Int Microbiol. 2000; 2(3):161-7. View

11.

Schubert S, Cuenca S, Fischer D, Heesemann J . High-pathogenicity island of Yersinia pestis in enterobacteriaceae isolated from blood cultures and urine samples: prevalence and functional expression. J Infect Dis. 2000; 182(4):1268-71. DOI: 10.1086/315831. View

12.

Clermont O, Bonacorsi S, Bingen E . The Yersinia high-pathogenicity island is highly predominant in virulence-associated phylogenetic groups of Escherichia coli. FEMS Microbiol Lett. 2001; 196(2):153-7. DOI: 10.1111/j.1574-6968.2001.tb10557.x. View

13.

Pelludat C, Hogardt M, Heesemann J . Transfer of the core region genes of the Yersinia enterocolitica WA-C serotype O:8 high-pathogenicity island to Y. enterocolitica MRS40, a strain with low levels of pathogenicity, confers a yersiniabactin biosynthesis phenotype and enhanced mouse.... Infect Immun. 2002; 70(4):1832-41. PMC: 127873. DOI: 10.1128/IAI.70.4.1832-1841.2002. View

14.

Kempi V . A FORTRAN program for ranking and for calculation of Spearman's correlation coefficient. Comput Methods Programs Biomed. 1985; 21(2):123-5. DOI: 10.1016/0169-2607(85)90072-0. View

15.

Herzer P, Inouye S, Inouye M, Whittam T . Phylogenetic distribution of branched RNA-linked multicopy single-stranded DNA among natural isolates of Escherichia coli. J Bacteriol. 1990; 172(11):6175-81. PMC: 526797. DOI: 10.1128/jb.172.11.6175-6181.1990. View

16.

Schubert S, Rakin A, Karch H, Carniel E, Heesemann J . Prevalence of the "high-pathogenicity island" of Yersinia species among Escherichia coli strains that are pathogenic to humans. Infect Immun. 1998; 66(2):480-5. PMC: 107931. DOI: 10.1128/IAI.66.2.480-485.1998. View